-transparent.png){kind=logo}
1. Urinary and faecal excretion of radioactivity in 120 h after oral administration of [U-14-C]phenyl o-(2-N-morpholinoethoxy)phenyl ether hydrochloride (200 mg/kg) were 92 and 3% dose in the rabbit, and 60 and 35% in the rat. 2. Urinary metabolites were produced by aromatic hydroxylation and aryl alkyl ether bond cleavage. Some evidence for formation of dioxomorpholino, oxohydroxymorpholino, and ethanolamino derivatives of the drug was obtained. 3. The aromatic hydroxylation product, p-hydroxyphenyl o-(2-N-morpholinoethoxy)phenyl ether hydrochloride had vasopressor activity comparable with the parent compound, but with shorter duration of action.
Related Publications
K Tatsumi, and
S Kitamura, and
H Yoshimura, and
S Tanaka, and
K Hashimoto
July 1985,
Xenobiotica; the fate of foreign compounds in biological systems,
K Tatsumi, and
S Kitamura, and
H Yoshimura, and
S Tanaka, and
K Hashimoto
January 1983,
Journal of agricultural and food chemistry,
K Tatsumi, and
S Kitamura, and
H Yoshimura, and
S Tanaka, and
K Hashimoto
November 2021,
International journal of biological macromolecules,
K Tatsumi, and
S Kitamura, and
H Yoshimura, and
S Tanaka, and
K Hashimoto
January 1965,
Federation proceedings. Translation supplement; selected translations from medical-related science,
K Tatsumi, and
S Kitamura, and
H Yoshimura, and
S Tanaka, and
K Hashimoto
April 1983,
Xenobiotica; the fate of foreign compounds in biological systems,
K Tatsumi, and
S Kitamura, and
H Yoshimura, and
S Tanaka, and
K Hashimoto
January 1970,
Journal of agricultural and food chemistry,
K Tatsumi, and
S Kitamura, and
H Yoshimura, and
S Tanaka, and
K Hashimoto
January 1982,
Archives of environmental contamination and toxicology,
K Tatsumi, and
S Kitamura, and
H Yoshimura, and
S Tanaka, and
K Hashimoto
October 1982,
Xenobiotica; the fate of foreign compounds in biological systems,
K Tatsumi, and
S Kitamura, and
H Yoshimura, and
S Tanaka, and
K Hashimoto
January 1970,
Indian journal of experimental biology,
K Tatsumi, and
S Kitamura, and
H Yoshimura, and
S Tanaka, and
K Hashimoto
September 2001,
Journal of the American Chemical Society,
