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In 56 patients with maturity onset diabetes receiving combined therapy with different oral hypoglycemic drugs, biguanide treatment was stopped while sulphonylurea compounds were continued without major changes. In four patients insulin therapy had to be initiated rapidly. In 14 other patients follow-up observations could not be performed for various reasons. The reamining 38 patients were divided into four groups according to their treatment. On the average, chemical control could not be maintained in any group after discontinuation of biguanide therapy. Blood glucose concentrations and glycosuria increased. Later, in 6 of 38 patients secondary failure of sulphonylurea treatment became apparent.
I Walter-Sack, and
G Wolfram, and
N Zöllner
December 1978,
Casopis lekaru ceskych,
I Walter-Sack, and
G Wolfram, and
N Zöllner
September 1976,
Therapeutische Umschau. Revue therapeutique,
I Walter-Sack, and
G Wolfram, and
N Zöllner
December 1980,
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I Walter-Sack, and
G Wolfram, and
N Zöllner
November 1974,
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I Walter-Sack, and
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N Zöllner
August 1981,
Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry,
I Walter-Sack, and
G Wolfram, and
N Zöllner
January 1977,
Deutsche medizinische Wochenschrift (1946),
I Walter-Sack, and
G Wolfram, and
N Zöllner
September 1974,
Casopis lekaru ceskych,
I Walter-Sack, and
G Wolfram, and
N Zöllner
March 1976,
Klinische Wochenschrift,
I Walter-Sack, and
G Wolfram, and
N Zöllner
February 1976,
Laryngologie, Rhinologie, Otologie,
I Walter-Sack, and
G Wolfram, and
N Zöllner
October 1974,
MMW, Munchener medizinische Wochenschrift,
