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The HemoDynamics Systems enabler is a new cardiac assist pump that can expel blood from the left ventricle and provide pulsatile flow in the aorta. We evaluated the efficacy of the 18 Fr enabler. The enabler was inserted from the left ventricular apex into the ascending aorta in eight sheep. Heart failure (mild, moderate, and severe) was induced by microsphere injection into the coronary arteries to reduce cardiac output by 10-30%, 31-50%, and more than 50% from baseline, respectively. The enabler was activated, and its flow was increased to approximately 2.0 L/min. Hemodynamic variables were recorded before and after activation. In moderate heart failure, cardiac output and mean aortic pressure increased from 2.3 +/- 0.6 L/min and 59 +/- 12 mm Hg before assist to 2.8 +/- 0.6 L/min and 70 +/- 8 mm Hg at 30 minutes after activation, respectively (p < 0.01). Left atrial pressure decreased from 17 +/- 3 to 13 +/- 4 mm Hg (p < 0.05). Similar findings were observed in mild and severe heart failure. Despite its small diameter, the enabler significantly improved the hemodynamics of failing hearts and may potentially serve as a means of peripheral left ventricular support. Further study is warranted.
M Takagaki, and
D Rottenberg, and
P M McCarthy, and
N G Smedira, and
R Dessoffy, and
M Al-Ahmadi, and
D Shoshani, and
K Fukamachi
January 2007,
ASAIO journal (American Society for Artificial Internal Organs : 1992),
M Takagaki, and
D Rottenberg, and
P M McCarthy, and
N G Smedira, and
R Dessoffy, and
M Al-Ahmadi, and
D Shoshani, and
K Fukamachi
January 2017,
ASAIO journal (American Society for Artificial Internal Organs : 1992),
M Takagaki, and
D Rottenberg, and
P M McCarthy, and
N G Smedira, and
R Dessoffy, and
M Al-Ahmadi, and
D Shoshani, and
K Fukamachi
March 2011,
Artificial organs,
M Takagaki, and
D Rottenberg, and
P M McCarthy, and
N G Smedira, and
R Dessoffy, and
M Al-Ahmadi, and
D Shoshani, and
K Fukamachi
August 1999,
The Annals of thoracic surgery,
M Takagaki, and
D Rottenberg, and
P M McCarthy, and
N G Smedira, and
R Dessoffy, and
M Al-Ahmadi, and
D Shoshani, and
K Fukamachi
August 2020,
Medicina (Kaunas, Lithuania),
M Takagaki, and
D Rottenberg, and
P M McCarthy, and
N G Smedira, and
R Dessoffy, and
M Al-Ahmadi, and
D Shoshani, and
K Fukamachi
December 2000,
Journal of cardiothoracic and vascular anesthesia,
M Takagaki, and
D Rottenberg, and
P M McCarthy, and
N G Smedira, and
R Dessoffy, and
M Al-Ahmadi, and
D Shoshani, and
K Fukamachi
November 2003,
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery,
M Takagaki, and
D Rottenberg, and
P M McCarthy, and
N G Smedira, and
R Dessoffy, and
M Al-Ahmadi, and
D Shoshani, and
K Fukamachi
December 2005,
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
M Takagaki, and
D Rottenberg, and
P M McCarthy, and
N G Smedira, and
R Dessoffy, and
M Al-Ahmadi, and
D Shoshani, and
K Fukamachi
April 2014,
The Journal of thoracic and cardiovascular surgery,
M Takagaki, and
D Rottenberg, and
P M McCarthy, and
N G Smedira, and
R Dessoffy, and
M Al-Ahmadi, and
D Shoshani, and
K Fukamachi
September 2016,
Journal of nuclear medicine technology,
