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Gas chromatograph/mass spectrometer/computer systems can be used to quantify a wide variety of compounds of clinical interest. A quadrupole instrument operated in the chemical ionization (Cl) mode was used in these studies. Because of the sensitivity and specificity of selective ion detection, it is possible to make measurements routinely in the nanogram to picogram range, with 0.1-1.0 ml samples of plasma and 1-5 ml samples or urine. Internal standards, preferably stable-isotope-labeled compounds, were added to the biological samples before isolation was begun. We describe clinical applications of these procedures to problems in toxicology, pharmacokinetics, and perinatal pharmacology.
M G Horning, and
J Nowlin, and
C M Butler, and
K Lertratanangkoon, and
K Sommer, and
R M Hill
May 1973,
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M G Horning, and
J Nowlin, and
C M Butler, and
K Lertratanangkoon, and
K Sommer, and
R M Hill
January 1984,
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M G Horning, and
J Nowlin, and
C M Butler, and
K Lertratanangkoon, and
K Sommer, and
R M Hill
June 1978,
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M G Horning, and
J Nowlin, and
C M Butler, and
K Lertratanangkoon, and
K Sommer, and
R M Hill
August 1997,
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M G Horning, and
J Nowlin, and
C M Butler, and
K Lertratanangkoon, and
K Sommer, and
R M Hill
July 1978,
Biomedical mass spectrometry,
M G Horning, and
J Nowlin, and
C M Butler, and
K Lertratanangkoon, and
K Sommer, and
R M Hill
August 1985,
Radioisotopes,
M G Horning, and
J Nowlin, and
C M Butler, and
K Lertratanangkoon, and
K Sommer, and
R M Hill
December 1978,
Biomedical mass spectrometry,
M G Horning, and
J Nowlin, and
C M Butler, and
K Lertratanangkoon, and
K Sommer, and
R M Hill
May 1985,
Clinical chemistry,
M G Horning, and
J Nowlin, and
C M Butler, and
K Lertratanangkoon, and
K Sommer, and
R M Hill
July 1985,
Talanta,
M G Horning, and
J Nowlin, and
C M Butler, and
K Lertratanangkoon, and
K Sommer, and
R M Hill
March 1979,
Bulletin of environmental contamination and toxicology,
