Biomaterial Database

Low dose intravenous immunoglobulin for acute immune thrombocytopenic purpura in children. 2001

I Nuchprayoon, and P Seksarn, and P Vanichsetakul, and R O-chareon

Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Acute immune thrombocytopenic purpura (ITP) is a self-limited autoimmune disorder to platelets. The disease responds well to intravenous immunoglobulin (IVIG) treatment. We studied the efficacy of low dose (1 g/kg) IVIG to treat acute ITP in children. Of 17 children with ITP and platelet counts < 20,000/microl, 13 (76%) had rapid platelet count recovery, reaching safe level (> 50,000/microl) within 4 days after 1 g/kg IVIG. Four children needed a second dose. In 5 of 15 patients, platelet counts recovered to normal without recurrence, while in 10 patients, platelet counts declined again 2-3 weeks after the initial treatment; 6 of whom (40%) needed re-treatment. All but one patient had complete recovery of the platelet count by 6 months. Adverse effects of low dose IVIG were minimal. We recommend that for childhood ITP, 1 g/kg IVIG should be tried initially. If inadequate response is seen (platelet count < 30,000/microl) by 48 hours, a second dose is needed.

UI	MeSH Term	Description	Entries
D007136	Immunoglobulins	Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.	Globulins, Immune,Immune Globulin,Immune Globulins,Immunoglobulin,Globulin, Immune
D007223	Infant	A child between 1 and 23 months of age.	Infants
D007229	Infant Welfare	Organized efforts by communities or organizations to improve the health and well-being of infants.	Infant Well-Being,Newborn Infant Welfare,Newborn Infant Well-Being,Welfare of Infants,Welfare of Newborn Infants,Infant Well Being,Infant Well-Being, Newborn,Infants Welfare,Newborn Infant Well Being,Welfare, Infant,Welfare, Newborn Infant,Well-Being, Infant,Well-Being, Newborn Infant
D007260	Infusion Pumps	Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders.	Drug Infusion Systems,Infusion Pump,Infusion Pumps, External,Infusors,Intravenous Drug Delivery System,Intravenous Drug Delivery Systems,Perfusion Pumps,Pumps, Infusion,Drug Infusion System,External Infusion Pump,External Infusion Pumps,Infusion Pump, External,Infusion System, Drug,Infusion Systems, Drug,Infusor,Perfusion Pump,Pump, External Infusion,Pump, Infusion,Pump, Perfusion,Pumps, External Infusion,Pumps, Perfusion,System, Drug Infusion,Systems, Drug Infusion
D008297	Male		Males
D010976	Platelet Count	The number of PLATELETS per unit volume in a sample of venous BLOOD.	Blood Platelet Count,Blood Platelet Number,Platelet Number,Blood Platelet Counts,Blood Platelet Numbers,Count, Blood Platelet,Count, Platelet,Counts, Blood Platelet,Counts, Platelet,Number, Blood Platelet,Number, Platelet,Numbers, Blood Platelet,Numbers, Platelet,Platelet Count, Blood,Platelet Counts,Platelet Counts, Blood,Platelet Number, Blood,Platelet Numbers,Platelet Numbers, Blood
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002669	Child Welfare	Organized efforts by communities or organizations to improve the health and well-being of the child.	Adolescent Welfare,Welfare, Adolescent,Welfare, Child
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D004306	Dose-Response Relationship, Immunologic	A specific immune response elicited by a specific dose of an immunologically active substance or cell in an organism, tissue, or cell.	Immunologic Dose-Response Relationship,Relationship, Immunologic Dose-Response,Dose Response Relationship, Immunologic,Dose-Response Relationships, Immunologic,Immunologic Dose Response Relationship,Immunologic Dose-Response Relationships,Relationship, Immunologic Dose Response,Relationships, Immunologic Dose-Response