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For the purpose of searching for new drug with high potency and simple chemical structure, the dominant conformation and structural parameters of Guan-Fu base (GFA) molecule were modelled and calculated with a SGI-4D 25G computer. The propanediolamine chain in GFA might be considered to be a pharmacophore responsible for the bioactivity and the configuration of the chain seemed important. Thus, thirteen compounds of (erythro)-p-x-PhCHOHCHOHCH2NHR(x = H, I1-7; X = NO2, II1-6) were prepared. Among them, 10 compounds showed antiarrhythmic effect on aconitine-induced arrhythmia in rats. The ED50(to stop VT) of I2 and ED50(to stop VP) of I3 were shown to be comparable with those of GFA. In the synthesis, no stereoselectivity was found in the Prevost reaction with allylamine analogues (a1-7). After a1-7 were acetylated, the erythro type products(I1-7) were obtained.
Y Ren, and
W Y Hua, and
S X Peng, and
D Y Zhu, and
Y L Guo
April 1972,
Journal of medicinal chemistry,
Y Ren, and
W Y Hua, and
S X Peng, and
D Y Zhu, and
Y L Guo
November 1974,
Journal of medicinal chemistry,
Y Ren, and
W Y Hua, and
S X Peng, and
D Y Zhu, and
Y L Guo
March 1963,
Zeitschrift fur Naturforschung. Teil B, Chemie, Biochemie, Biophysik, Biologie und verwandte Gebiete,
Y Ren, and
W Y Hua, and
S X Peng, and
D Y Zhu, and
Y L Guo
January 1990,
Yao xue xue bao = Acta pharmaceutica Sinica,
Y Ren, and
W Y Hua, and
S X Peng, and
D Y Zhu, and
Y L Guo
June 1987,
Die Pharmazie,
Y Ren, and
W Y Hua, and
S X Peng, and
D Y Zhu, and
Y L Guo
January 1997,
Acta poloniae pharmaceutica,
Y Ren, and
W Y Hua, and
S X Peng, and
D Y Zhu, and
Y L Guo
May 2002,
European journal of medicinal chemistry,
Y Ren, and
W Y Hua, and
S X Peng, and
D Y Zhu, and
Y L Guo
February 2012,
Steroids,
Y Ren, and
W Y Hua, and
S X Peng, and
D Y Zhu, and
Y L Guo
February 1946,
Nature,
Y Ren, and
W Y Hua, and
S X Peng, and
D Y Zhu, and
Y L Guo
July 1970,
Journal of medicinal chemistry,
