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OBJECTIVE To compare two quantitative pilocarpine iontophoresis tests for sweat chloride. METHODS Simultaneous right and left arm sweat tests were done with the Gibson/Cooke and the CF quantum technologies. METHODS Sweat tests were performed in a quality controlled cystic fibrosis (CF) sweat test laboratory by an experienced technologist at the University of Minnesota CF Center. METHODS Patients referred for sweat tests as well as volunteer CF and control subjects (50 CF and 114 'normals') were tested. METHODS Standard procedures were used for the Gibson/Cooke test (GCST). The manufacturer of the CF quantum test (CFQT) provided factory standardized materials. METHODS Sweat chloride concentration, test time, failed tests, sensitivity, specificity, and cost. RESULTS Duplicate test comparing the CFQT and the GCST revealed good comparability (R2 = 0.9434). Sensitivity and specificity of the two methods are comparable at about 94% and 99% respectively. Rate of failed tests was 1% for the CFQT and 15% for the GCST. The CFQT and the GCST are comparable (R2 = 0.9434). Sensitivity (94%) and specificity (99%) are the same for both tests. CONCLUSIONS The CFQT method is equal in accuracy and reliability to the more labor-intensive and costly GCST. Advantages of the CFQT are: the small sample size required (three to ten mg), decreased operator dependence, simpler to perform, and requires less equipment. It could be used in a clinic setting to diagnose CF in patients with suggestive symptoms.
W J Warwick, and
L G Hansen, and
I V Brown, and
W C Laine, and
K L Hansen
May 2024,
Biosensors & bioelectronics,
W J Warwick, and
L G Hansen, and
I V Brown, and
W C Laine, and
K L Hansen
January 1980,
Biomaterials, medical devices, and artificial organs,
W J Warwick, and
L G Hansen, and
I V Brown, and
W C Laine, and
K L Hansen
August 1956,
A.M.A. journal of diseases of children,
W J Warwick, and
L G Hansen, and
I V Brown, and
W C Laine, and
K L Hansen
November 1984,
Clinical pediatrics,
W J Warwick, and
L G Hansen, and
I V Brown, and
W C Laine, and
K L Hansen
March 1997,
Annals of clinical biochemistry,
W J Warwick, and
L G Hansen, and
I V Brown, and
W C Laine, and
K L Hansen
June 2021,
ACS sensors,
W J Warwick, and
L G Hansen, and
I V Brown, and
W C Laine, and
K L Hansen
May 2022,
Analytical chemistry,
W J Warwick, and
L G Hansen, and
I V Brown, and
W C Laine, and
K L Hansen
January 1962,
The Journal of the American Osteopathic Association,
W J Warwick, and
L G Hansen, and
I V Brown, and
W C Laine, and
K L Hansen
November 2023,
Analytical methods : advancing methods and applications,
W J Warwick, and
L G Hansen, and
I V Brown, and
W C Laine, and
K L Hansen
July 2006,
Pancreas,
