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In order to investigate the effect of cyproheptadine, a compound with antiserotoninergic activity, on the secretion of thyrotrophin (TSH) and prolactin (PRL), the nocturnal secretory patterns of these hormones have been studied in 4 normal men in the basal state and after an oral treatment with the drug. In addition, the TSH and PRL responses to TRH of 6 women were compared in the basal conditions and after cyproheptadine treatment. The TSH nocturnal secretion was slightly modified by drug treatment. The response to TRH as well as the basal levels were comparable in the treated and non-treated subjects. In contrast, the PRL secretion measured through the nocturnal investigation was significantly inhibited by cyproheptadine administration as were the PRL basal levels in the TRH test. The PRL response to TRH was comparable in both situations.
J Golstein, and
L Vanhaelst, and
O D Bruno, and
M L'Hermite
September 1976,
Clinical endocrinology,
J Golstein, and
L Vanhaelst, and
O D Bruno, and
M L'Hermite
November 1974,
The Journal of endocrinology,
J Golstein, and
L Vanhaelst, and
O D Bruno, and
M L'Hermite
September 1976,
Clinical endocrinology,
J Golstein, and
L Vanhaelst, and
O D Bruno, and
M L'Hermite
December 1981,
Archives internationales de pharmacodynamie et de therapie,
J Golstein, and
L Vanhaelst, and
O D Bruno, and
M L'Hermite
January 1977,
The Journal of clinical endocrinology and metabolism,
J Golstein, and
L Vanhaelst, and
O D Bruno, and
M L'Hermite
February 1984,
Acta endocrinologica,
J Golstein, and
L Vanhaelst, and
O D Bruno, and
M L'Hermite
November 1977,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
J Golstein, and
L Vanhaelst, and
O D Bruno, and
M L'Hermite
January 1988,
Chronobiology international,
J Golstein, and
L Vanhaelst, and
O D Bruno, and
M L'Hermite
January 1979,
Clinical endocrinology,
J Golstein, and
L Vanhaelst, and
O D Bruno, and
M L'Hermite
July 1975,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
