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We report on four children with heparin-induced thrombocytopenia type II. In three patients, therapy with unfractionated heparin was associated with development of cardiac thrombi or with thrombosis progression up to the inferior vena cava or with aggravation of peripheral arterial occlusion. In the fourth child, the disease was recognized early on, and no complication occurred. Heparin-induced thrombocytopenia type II was confirmed by heparin-induced platelet activation assay and/or heparin/platelet factor 4-ELISA. Concomitant elevated antiphospholipid antibodies were seen in all patients. Danaparoid sodium applied at a dosage of between 1.2 and 7.1 U/kg/h stopped the disease progression in each patient. Three children had a clinical recovery with partial recanalization, but for the child with peripheral arterial occlusion disease, amputation of some of the toes became necessary. CONCLUSIONS Our data indicate that heparin-induced thrombocytopenia type II is a potential life-threatening disease in children and danaparoid sodium is beneficial in this age group.
B Zöhrer', and
W Zenz, and
A Rettenbacher, and
P Covi, and
K Kurnik, and
H Kroll, and
H M Grubbauer, and
W Muntean
September 1999,
The Annals of thoracic surgery,
B Zöhrer', and
W Zenz, and
A Rettenbacher, and
P Covi, and
K Kurnik, and
H Kroll, and
H M Grubbauer, and
W Muntean
January 2003,
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis,
B Zöhrer', and
W Zenz, and
A Rettenbacher, and
P Covi, and
K Kurnik, and
H Kroll, and
H M Grubbauer, and
W Muntean
January 1998,
Annales francaises d'anesthesie et de reanimation,
B Zöhrer', and
W Zenz, and
A Rettenbacher, and
P Covi, and
K Kurnik, and
H Kroll, and
H M Grubbauer, and
W Muntean
November 2001,
Annales francaises d'anesthesie et de reanimation,
B Zöhrer', and
W Zenz, and
A Rettenbacher, and
P Covi, and
K Kurnik, and
H Kroll, and
H M Grubbauer, and
W Muntean
January 1992,
Haemostasis,
B Zöhrer', and
W Zenz, and
A Rettenbacher, and
P Covi, and
K Kurnik, and
H Kroll, and
H M Grubbauer, and
W Muntean
August 2000,
Pediatric nephrology (Berlin, Germany),
B Zöhrer', and
W Zenz, and
A Rettenbacher, and
P Covi, and
K Kurnik, and
H Kroll, and
H M Grubbauer, and
W Muntean
November 1995,
British journal of haematology,
B Zöhrer', and
W Zenz, and
A Rettenbacher, and
P Covi, and
K Kurnik, and
H Kroll, and
H M Grubbauer, and
W Muntean
June 2000,
Journal of clinical anesthesia,
B Zöhrer', and
W Zenz, and
A Rettenbacher, and
P Covi, and
K Kurnik, and
H Kroll, and
H M Grubbauer, and
W Muntean
August 1998,
The Annals of thoracic surgery,
B Zöhrer', and
W Zenz, and
A Rettenbacher, and
P Covi, and
K Kurnik, and
H Kroll, and
H M Grubbauer, and
W Muntean
July 1995,
Zeitschrift fur Kardiologie,
