BIOMAT Database Logo BIOMAT Database Logo

High frequency of allelic imbalance at regions of chromosome arm 8p in ovarian carcinoma. 2001

I Pribill, and P Speiser, and J Leary, and S Leodolter, and N F Hacker, and M L Friedlander, and D Birnbaum, and R Zeillinger, and M Krainer
Department of Medicine I, Clinical Division of Oncology, University Hospital, Molecular Oncology Group, Währingergürtel 18-20, A-1090 Vienna, Austria.

Progressive genetic changes such as the inactivation of tumor suppressor genes (TSG) are thought to play an important role in the initiation and progression of ovarian cancer. Frequent nonrandom allelic imbalance (AI) at 8p11-p21 and 8p22-pter suggests the existence of TSGs that may be involved in the carcinogenesis of several human malignancies. We investigated 70 ovarian tumors with 11 highly polymorphic markers spanning 8p12-p21 and 8p22-pter to produce an AI map of 8p in epithelial ovarian cancer. Allelic imbalance was demonstrated in 54 tumors (77%), most frequently occurring at D8S136 (54%) and at D8S1992 (55%). Poorly differentiated and advanced stage cancers were more often affected by AI (G1+G2 vs. G3; 20% vs. 66%; stage I+II vs. III+IV, 36% vs. 54%, P<.001; Kruskal-Wallis test) than well differentiated and early stage tumors. There was no relationship between histological subtype and AI. Smallest regions of overlap (SRO) were delineated by analyzing 38 tumors with partial AI. This study provides compelling evidence for the involvement of TSGs on the short arm of chromosome 8, at 8p12-p21 and at 8p23 in the development and progression of epithelial ovarian cancer.

UI MeSH Term Description Entries
D010051 Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. Cancer of Ovary,Ovarian Cancer,Cancer of the Ovary,Neoplasms, Ovarian,Ovary Cancer,Ovary Neoplasms,Cancer, Ovarian,Cancer, Ovary,Cancers, Ovarian,Cancers, Ovary,Neoplasm, Ovarian,Neoplasm, Ovary,Neoplasms, Ovary,Ovarian Cancers,Ovarian Neoplasm,Ovary Cancers,Ovary Neoplasm
D002898 Chromosomes, Human, Pair 8 A specific pair of GROUP C CHROMOSOMES of the human chromosome classification. Chromosome 8
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016147 Genes, Tumor Suppressor Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible. Antioncogenes,Cancer Suppressor Genes,Emerogenes,Genes, Cancer Suppressor,Genes, Growth Suppressor,Genes, Metastasis Suppressor,Growth Suppressor Genes,Metastasis Suppressor Genes,Tumor Suppressor Genes,Anti-Oncogenes,Genes, Onco-Suppressor,Oncogenes, Recessive,Tumor Suppressing Genes,Anti Oncogenes,Anti-Oncogene,Antioncogene,Cancer Suppressor Gene,Emerogene,Gene, Cancer Suppressor,Gene, Growth Suppressor,Gene, Metastasis Suppressor,Gene, Onco-Suppressor,Gene, Tumor Suppressing,Gene, Tumor Suppressor,Genes, Onco Suppressor,Genes, Tumor Suppressing,Growth Suppressor Gene,Metastasis Suppressor Gene,Onco-Suppressor Gene,Onco-Suppressor Genes,Oncogene, Recessive,Recessive Oncogene,Recessive Oncogenes,Suppressor Gene, Cancer,Suppressor Gene, Growth,Suppressor Gene, Metastasis,Suppressor Genes, Cancer,Suppressor Genes, Growth,Suppressor Genes, Metastasis,Tumor Suppressing Gene,Tumor Suppressor Gene
D019656 Loss of Heterozygosity The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted. Allelic Loss,Heterozygosity, Loss of,Allelic Losses,Heterozygosity Loss
D022981 Allelic Imbalance A situation where one member (allele) of a gene pair is lost (LOSS OF HETEROZYGOSITY) or amplified. Allelic Imbalances,Imbalance, Allelic,Imbalances, Allelic

Related Publications

I Pribill, and P Speiser, and J Leary, and S Leodolter, and N F Hacker, and M L Friedlander, and D Birnbaum, and R Zeillinger, and M Krainer
Loss of chromosome arm 8p loci in prostate cancer: mapping by quantitative allelic imbalance.
July 1994, Genes, chromosomes & cancer,
I Pribill, and P Speiser, and J Leary, and S Leodolter, and N F Hacker, and M L Friedlander, and D Birnbaum, and R Zeillinger, and M Krainer
Allelic loss on chromosome arm 8p: analysis of sporadic epithelial ovarian tumors.
July 1999, Gynecologic oncology,
I Pribill, and P Speiser, and J Leary, and S Leodolter, and N F Hacker, and M L Friedlander, and D Birnbaum, and R Zeillinger, and M Krainer
At least two different regions are involved in allelic imbalance on chromosome arm 16q in breast cancer.
February 1994, Genes, chromosomes & cancer,
I Pribill, and P Speiser, and J Leary, and S Leodolter, and N F Hacker, and M L Friedlander, and D Birnbaum, and R Zeillinger, and M Krainer
Allelic imbalance of chromosome 6q in ovarian tumours.
April 1995, British journal of cancer,
I Pribill, and P Speiser, and J Leary, and S Leodolter, and N F Hacker, and M L Friedlander, and D Birnbaum, and R Zeillinger, and M Krainer
Allelic loss at chromosome 8p in human breast-cancer.
March 1994, Oncology reports,
I Pribill, and P Speiser, and J Leary, and S Leodolter, and N F Hacker, and M L Friedlander, and D Birnbaum, and R Zeillinger, and M Krainer
Deletion mapping defines three discrete areas of allelic imbalance on chromosome arm 8p in oral and oropharyngeal squamous cell carcinomas.
December 1997, Genes, chromosomes & cancer,
I Pribill, and P Speiser, and J Leary, and S Leodolter, and N F Hacker, and M L Friedlander, and D Birnbaum, and R Zeillinger, and M Krainer
Allelic imbalance on the long arm of chromosome 5 in oral squamous cell carcinoma.
March 1997, International journal of oncology,
I Pribill, and P Speiser, and J Leary, and S Leodolter, and N F Hacker, and M L Friedlander, and D Birnbaum, and R Zeillinger, and M Krainer
High-resolution analysis of genomic alteration on chromosome arm 8p in urothelial carcinoma.
July 2010, Genes, chromosomes & cancer,
I Pribill, and P Speiser, and J Leary, and S Leodolter, and N F Hacker, and M L Friedlander, and D Birnbaum, and R Zeillinger, and M Krainer
Allelic imbalance in selected chromosomal regions in ovarian cancer.
November 2002, Cancer genetics and cytogenetics,
I Pribill, and P Speiser, and J Leary, and S Leodolter, and N F Hacker, and M L Friedlander, and D Birnbaum, and R Zeillinger, and M Krainer
Allelic imbalance at chromosome 1q21 in Wilms tumor.
August 1997, Cancer genetics and cytogenetics,
Copied contents to your clipboard!