-transparent.png){kind=logo}
In order to examine the toxicity of magnesium chloride hexahydrate, four groups of 10 male and 10 female F344 rats received the compound by dietary supplementation at 2.5, 0.5, 0.1 or 0% for 90 days. No treatment-related death was observed during the study. Transient soft stool and sustained increase in water consumption were observed both in males and females of the 2.5% group and slight reduction in body weight gain was noted in the high-dose males. There were no toxic changes in food consumption, organ weights, hematology and biochemistry, and histopathological examinations in any treated-groups. Based on these results, the no-observed-adverse-effect-level was estimated to be 0.5%, and 2.5% is considered to be appropriate as highest dose for a 2-year carcinogenicity study.
T Takizawa, and
K Yasuhara, and
K Mitsumori, and
H Onodera, and
T Koujitani, and
T Tamura, and
H Takagi, and
M Hirose
June 2022,
Environmental analysis, health and toxicology,
T Takizawa, and
K Yasuhara, and
K Mitsumori, and
H Onodera, and
T Koujitani, and
T Tamura, and
H Takagi, and
M Hirose
May 2018,
Biomedical and environmental sciences : BES,
T Takizawa, and
K Yasuhara, and
K Mitsumori, and
H Onodera, and
T Koujitani, and
T Tamura, and
H Takagi, and
M Hirose
January 1994,
Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences,
T Takizawa, and
K Yasuhara, and
K Mitsumori, and
H Onodera, and
T Koujitani, and
T Tamura, and
H Takagi, and
M Hirose
February 2012,
The Journal of toxicological sciences,
T Takizawa, and
K Yasuhara, and
K Mitsumori, and
H Onodera, and
T Koujitani, and
T Tamura, and
H Takagi, and
M Hirose
April 2022,
Biomedical and environmental sciences : BES,
T Takizawa, and
K Yasuhara, and
K Mitsumori, and
H Onodera, and
T Koujitani, and
T Tamura, and
H Takagi, and
M Hirose
April 2019,
Toxicological research,
T Takizawa, and
K Yasuhara, and
K Mitsumori, and
H Onodera, and
T Koujitani, and
T Tamura, and
H Takagi, and
M Hirose
January 2018,
Toxicology reports,
T Takizawa, and
K Yasuhara, and
K Mitsumori, and
H Onodera, and
T Koujitani, and
T Tamura, and
H Takagi, and
M Hirose
January 2000,
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences,
T Takizawa, and
K Yasuhara, and
K Mitsumori, and
H Onodera, and
T Koujitani, and
T Tamura, and
H Takagi, and
M Hirose
July 2020,
Regulatory toxicology and pharmacology : RTP,
T Takizawa, and
K Yasuhara, and
K Mitsumori, and
H Onodera, and
T Koujitani, and
T Tamura, and
H Takagi, and
M Hirose
January 1999,
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyujo hokoku = Bulletin of National Institute of Health Sciences,
