-transparent.png){kind=logo}
The condensation of 2-methyl-3-amino-4(3H)-quinazolinone and 2-phenyl-3-amino-4(3H)-quinazolinone with different aldehydes is described. Reacting equimolecular amounts of these two amino compounds with p-nitrobenzaldehyde, p-hydroxybenzaldehyde, cinnamaldehyde and 5-nitro-2-furfuraldehyde diacetate afforded the respective Schiff's bases. Condensation of benzaldehyde, anisaldehyde, p-dimethylaminobenzaldehyde and o-nitrobenzaldehyde with the former quinazolinone afforded the corresponding condensation products while with the latter no condensation took place. Furthermore, condensation of cinnamaldehyde with methylaminoquinazolinone in pyridine and in glacial acetic acid afforded the mono- and di-condensation products respectively while furfural, thiophenaldehyde, resorcinaldehyde, protocatechualdehyde, veratraldehyde, and salicylaldehyde, the condensation ended in failure.
S M Roshdy, and
K M Ghoneim, and
M Khalifa
April 1978,
Die Pharmazie,
S M Roshdy, and
K M Ghoneim, and
M Khalifa
March 1966,
Journal of medicinal chemistry,
S M Roshdy, and
K M Ghoneim, and
M Khalifa
June 1977,
Die Pharmazie,
S M Roshdy, and
K M Ghoneim, and
M Khalifa
October 1996,
Chemical & pharmaceutical bulletin,
S M Roshdy, and
K M Ghoneim, and
M Khalifa
March 1966,
Journal of pharmaceutical sciences,
S M Roshdy, and
K M Ghoneim, and
M Khalifa
January 1976,
Die Pharmazie,
S M Roshdy, and
K M Ghoneim, and
M Khalifa
October 1978,
Die Pharmazie,
S M Roshdy, and
K M Ghoneim, and
M Khalifa
March 1990,
Chemical & pharmaceutical bulletin,
S M Roshdy, and
K M Ghoneim, and
M Khalifa
December 1966,
Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft,
S M Roshdy, and
K M Ghoneim, and
M Khalifa
January 1966,
Journal of medicinal chemistry,
