In September the Space Shuttle Columbia mission Spacelab Life Sciences-2 (SLS-2) was the second Spacelab flight dedicated to life sciences research. Columbia's seven crew members performed a series of experiments to gain more knowledge on how the human body adapts to the weightless environment of space during the flight and after returning to Earth. The STS-58 crew performed experiments focusing on the cardiovascular, regulatory, neurovestibular and musculoskeletal systems of the body. Fourteen total experiments, with eight experiments performed on Columbia's crew and six on laboratory animals, along with data collected on the SLS-1 mission in June 1991, will provide the most detailed and interrelated physiological measurements acquired in the space environment since the Skylab program in 1973 and 1974.