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Rat tail-suspension induces disuse atrophy of muscles and bones in hindlimbs. In the present investigation we studied how ovariectomy and estrogen substitution affect the development of the disuse atrophy induced by suspension. Five-week old female Wistar rats were ovariectomized and divided into two groups. One group received intramuscular injection of estradiol dipropionate once a week (OVX-E2 group), and the other received a vehicle injection (OVX group). After the third injection, each group was further divided into two groups, tail-suspended and non-suspended. After 7 days of tail-suspension, a significant decrease in the wet weight of femurs and their Ca and Pi content was observed in the OVX group. However, no significant change in those parameters was observed in the E2 group. In both E2 and OVX groups, a significant decrease in the wet weight of soleus and gastrocnemius muscles was demonstrated after the suspension. This demonstrated that estrogen administration to ovariectomized rats prevents the development of disuse bone atrophy but not that of muscle atrophy, suggesting that estrogen plays important roles in bone remodeling.
S Kawano, and
K Kanda, and
S Ohmori, and
R Izumi, and
K Yasukawa, and
Y Murata, and
H Seo
October 1997,
Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University,
S Kawano, and
K Kanda, and
S Ohmori, and
R Izumi, and
K Yasukawa, and
Y Murata, and
H Seo
January 1968,
Calcified tissue research,
S Kawano, and
K Kanda, and
S Ohmori, and
R Izumi, and
K Yasukawa, and
Y Murata, and
H Seo
December 2010,
The Journal of surgical research,
S Kawano, and
K Kanda, and
S Ohmori, and
R Izumi, and
K Yasukawa, and
Y Murata, and
H Seo
June 2006,
Journal of applied physiology (Bethesda, Md. : 1985),
S Kawano, and
K Kanda, and
S Ohmori, and
R Izumi, and
K Yasukawa, and
Y Murata, and
H Seo
October 2005,
Journal of applied physiology (Bethesda, Md. : 1985),
S Kawano, and
K Kanda, and
S Ohmori, and
R Izumi, and
K Yasukawa, and
Y Murata, and
H Seo
January 2014,
Physiological research,
S Kawano, and
K Kanda, and
S Ohmori, and
R Izumi, and
K Yasukawa, and
Y Murata, and
H Seo
January 2015,
Evidence-based complementary and alternative medicine : eCAM,
S Kawano, and
K Kanda, and
S Ohmori, and
R Izumi, and
K Yasukawa, and
Y Murata, and
H Seo
January 1970,
Acta pathologica et microbiologica Scandinavica. Section A, Pathology,
S Kawano, and
K Kanda, and
S Ohmori, and
R Izumi, and
K Yasukawa, and
Y Murata, and
H Seo
October 2009,
Biogerontology,
S Kawano, and
K Kanda, and
S Ohmori, and
R Izumi, and
K Yasukawa, and
Y Murata, and
H Seo
December 1990,
Nihon Seikeigeka Gakkai zasshi,
