BIOMAT Database Logo BIOMAT Database Logo

Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. 2001

E Kapiteijn, and C A Marijnen, and I D Nagtegaal, and H Putter, and W H Steup, and T Wiggers, and H J Rutten, and L Pahlman, and B Glimelius, and J H van Krieken, and J W Leer, and C J van de Velde, and
Department of Surgery, Leiden University Medical Center, The Netherlands.

BACKGROUND Short-term preoperative radiotherapy and total mesorectal excision have each been shown to improve local control of disease in patients with resectable rectal cancer. We conducted a multicenter, randomized trial to determine whether the addition of preoperative radiotherapy increases the benefit of total mesorectal excision. METHODS We randomly assigned 1861 patients with resectable rectal cancer either to preoperative radiotherapy (5 Gy on each of five days) followed by total mesorectal excision (924 patients) or to total mesorectal excision alone (937 patients). The trial was conducted with the use of standardization and quality-control measures to ensure the consistency of the radiotherapy, surgery, and pathological techniques. RESULTS Of the 1861 patients randomly assigned to one of the two treatment groups, 1805 were eligible to participate. The overall rate of survival at two years among the eligible patients was 82.0 percent in the group assigned to both radiotherapy and surgery and 81.8 percent in the group assigned to surgery alone (P=0.84). Among the 1748 patients who underwent a macroscopically complete local resection, the rate of local recurrence at two years was 5.3 percent. The rate of local recurrence at two years was 2.4 percent in the radiotherapy-plus-surgery group and 8.2 percent in the surgery-only group (P<0.001). CONCLUSIONS Short-term preoperative radiotherapy reduces the risk of local recurrence in patients with rectal cancer who undergo a standardized total mesorectal excision.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009364 Neoplasm Recurrence, Local The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site. Local Neoplasm Recurrence,Local Neoplasm Recurrences,Locoregional Neoplasm Recurrence,Neoplasm Recurrence, Locoregional,Neoplasm Recurrences, Local,Recurrence, Local Neoplasm,Recurrence, Locoregional Neoplasm,Recurrences, Local Neoplasm,Locoregional Neoplasm Recurrences,Neoplasm Recurrences, Locoregional,Recurrences, Locoregional Neoplasm
D011300 Preoperative Care Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed) Care, Preoperative,Preoperative Procedure,Preoperative Procedures,Procedure, Preoperative,Procedures, Preoperative
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D012004 Rectal Neoplasms Tumors or cancer of the RECTUM. Cancer of Rectum,Rectal Cancer,Rectal Tumors,Cancer of the Rectum,Neoplasms, Rectal,Rectum Cancer,Rectum Neoplasms,Cancer, Rectal,Cancer, Rectum,Neoplasm, Rectal,Neoplasm, Rectum,Rectal Cancers,Rectal Neoplasm,Rectal Tumor,Rectum Cancers,Rectum Neoplasm,Tumor, Rectal
D012007 Rectum The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL. Rectums
D003107 Colorectal Surgery A surgical specialty concerned with the diagnosis and treatment of disorders and abnormalities of the COLON; RECTUM; and ANAL CANAL. Proctology,Colon Surgery Specialty,Colon and Rectal Surgery Specialty,Rectal Surgery Specialty,Specialty, Colon Surgery,Specialty, Rectal Surgery,Surgery Specialty, Colon,Surgery Specialty, Colon and Rectal,Surgery Specialty, Rectal,Surgery, Colorectal
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

E Kapiteijn, and C A Marijnen, and I D Nagtegaal, and H Putter, and W H Steup, and T Wiggers, and H J Rutten, and L Pahlman, and B Glimelius, and J H van Krieken, and J W Leer, and C J van de Velde, and
[Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer].
December 2001, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al],
E Kapiteijn, and C A Marijnen, and I D Nagtegaal, and H Putter, and W H Steup, and T Wiggers, and H J Rutten, and L Pahlman, and B Glimelius, and J H van Krieken, and J W Leer, and C J van de Velde, and
Late toxicity after short course preoperative radiotherapy and total mesorectal excision for resectable rectal cancer.
August 2003, Clinical oncology (Royal College of Radiologists (Great Britain)),
E Kapiteijn, and C A Marijnen, and I D Nagtegaal, and H Putter, and W H Steup, and T Wiggers, and H J Rutten, and L Pahlman, and B Glimelius, and J H van Krieken, and J W Leer, and C J van de Velde, and
[Efficacy of preoperative radiotherapy combined with total mesorectal excision in the treatment of locally resectable rectal cancer: a systematic review].
March 2010, Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery,
E Kapiteijn, and C A Marijnen, and I D Nagtegaal, and H Putter, and W H Steup, and T Wiggers, and H J Rutten, and L Pahlman, and B Glimelius, and J H van Krieken, and J W Leer, and C J van de Velde, and
Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial.
June 2011, The Lancet. Oncology,
E Kapiteijn, and C A Marijnen, and I D Nagtegaal, and H Putter, and W H Steup, and T Wiggers, and H J Rutten, and L Pahlman, and B Glimelius, and J H van Krieken, and J W Leer, and C J van de Velde, and
Canadian Association of General Surgeons Evidence Based Reviews in Surgery. 5. Need for preoperative radiation in rectal cancer. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer.
February 2003, Canadian journal of surgery. Journal canadien de chirurgie,
E Kapiteijn, and C A Marijnen, and I D Nagtegaal, and H Putter, and W H Steup, and T Wiggers, and H J Rutten, and L Pahlman, and B Glimelius, and J H van Krieken, and J W Leer, and C J van de Velde, and
Preoperative radiotherapy combined with intraoperative radiotherapy improve results of total mesorectal excision in patients with T3 rectal cancer.
February 2004, Diseases of the colon and rectum,
E Kapiteijn, and C A Marijnen, and I D Nagtegaal, and H Putter, and W H Steup, and T Wiggers, and H J Rutten, and L Pahlman, and B Glimelius, and J H van Krieken, and J W Leer, and C J van de Velde, and
Local recurrence of rectal cancer after total mesorectal excision without preoperative radiotherapy.
January 2003, International journal of gastrointestinal cancer,
E Kapiteijn, and C A Marijnen, and I D Nagtegaal, and H Putter, and W H Steup, and T Wiggers, and H J Rutten, and L Pahlman, and B Glimelius, and J H van Krieken, and J W Leer, and C J van de Velde, and
Preoperative concurrent radiotherapy with capecitabine before total mesorectal excision in locally advanced rectal cancer.
October 2005, International journal of radiation oncology, biology, physics,
E Kapiteijn, and C A Marijnen, and I D Nagtegaal, and H Putter, and W H Steup, and T Wiggers, and H J Rutten, and L Pahlman, and B Glimelius, and J H van Krieken, and J W Leer, and C J van de Velde, and
[Adjuvant radiotherapy in rectal cancer and total mesorectal excision].
January 2001, Annali italiani di chirurgia,
E Kapiteijn, and C A Marijnen, and I D Nagtegaal, and H Putter, and W H Steup, and T Wiggers, and H J Rutten, and L Pahlman, and B Glimelius, and J H van Krieken, and J W Leer, and C J van de Velde, and
Transanal Total Mesorectal Excision Versus Laparoscopic Total Mesorectal Excision for Rectal Cancer.
June 2021, Diseases of the colon and rectum,
Copied contents to your clipboard!