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Structure-activity relationships of apio nucleosides as potential antiviral agents. 2001
L S Jeong, and
H R Moon, and
J H Hong, and
S J Yoo, and
W J Choi, and
H O Kim, and
H S Ahn, and
H W Baek, and
M W Chun, and
H D Kim, and
J Kim, and
J R Choi
College of Pharmacy, Ewha Womans University, Seoul, Korea.
Several types of novel apio nucleosides were synthesized starting from 1,3-dihydroxyacetone and evaluated for antiviral activity. Among compounds tested, amino substituted apio dideoxynucleosides exhibited anti-HBV activity, while thioapio dideoxynucleosides were found to be active against HIV-1. Apio dideoxydidehydro nucleosides showed moderate to potent anti-HCMV activity, but their bioisosteric thioapio dideoxydidehydro nucleosides did not exhibit any significant antiviral activity.
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