BIOMAT Database Logo BIOMAT Database Logo

PRL-releasing peptide inhibits food intake in male rats via the dorsomedial hypothalamic nucleus and not the paraventricular hypothalamic nucleus. 2001

L J Seal, and C J Small, and W S Dhillo, and S A Stanley, and C R Abbott, and M A Ghatei, and S R Bloom
Department of Metabolic Medicine, Imperial College School of Medicine, London, United Kingdom W12 0NN.

PRL-releasing peptide inhibits food intake after intracerebroventricular injection. PRL-releasing peptide immunoreactivity is found in several hypothalamic nuclei involved in feeding, with highest levels in the paraventricular and dorsomedial hypothalamic nuclei. The aim of this study was to examine the effect of PRL-releasing peptide on food intake after administration into these nuclei. Paraventricular nucleus injection of PRL-releasing peptide did not alter food intake. Dorsomedial hypothalamic nucleus injection of PRL-releasing peptide decreased 1 h food intake [PRL-releasing peptide (1 nmol) 83.4 +/- 6.1% saline all; P < 0.05]; and continued until 8 h postinjection [PRL-releasing peptide (1 nmol) 89.2 +/- 4.1% saline; P < 0.05]. To investigate the mechanism of this inhibition of food intake, we examined PRL-releasing peptide's effect on neuropeptide release from hypothalamic explants. alpha MSH release was increased [PRL-releasing peptide (100 nmol), 5.4 +/- 1.6 pmol/explant; change vs. basal, P < 0.01], whereas agouti-related protein release was unchanged. The release of cocaine- and amphetamine-regulated transcript was inhibited [PRL-releasing peptide (100 nmol), -33.5 +/- 12.6 pmol/explant; change vs. basal, P < 0.01]. PRL-releasing peptide dose-dependently increased neurotensin release [PRL-releasing peptide (1 nmol), 3.7 +/- 2.6 pmol/explant; change vs. basal, P = NS; PRL-releasing peptide (10 nmol), 7.2 +/- 2.7 pmol/explant; change vs. basal, P < 0.01; PRL-releasing peptide (100 nmol), 36.8 +/- 5.4 pmol/explant; change vs. basal, P < 0.001]. Our data suggest that the dorsomedial hypothalamic nucleus is important in the inhibitory effect of PRL-releasing peptide on food intake and that PRL-releasing peptide alters the release of several hypothalamic neuropeptides important in the control of food intake.

UI MeSH Term Description Entries
D007028 Hypothalamic Hormones Peptide hormones produced by NEURONS of various regions in the HYPOTHALAMUS. They are released into the pituitary portal circulation to stimulate or inhibit PITUITARY GLAND functions. VASOPRESSIN and OXYTOCIN, though produced in the hypothalamus, are not included here for they are transported down the AXONS to the POSTERIOR LOBE OF PITUITARY before being released into the portal circulation. Hypothalamic Pituitary-Regulating Hormones,Hypothalamic Pituitary-Regulating Peptides,Hormones, Hypothalamic,Hormones, Hypothalamic Pituitary-Regulating,Hypothalamic Pituitary Regulating Hormones,Hypothalamic Pituitary Regulating Peptides,Peptides, Hypothalamic Pituitary-Regulating,Pituitary-Regulating Hormones, Hypothalamic,Pituitary-Regulating Peptides, Hypothalamic
D008297 Male Males
D009479 Neuropeptides Peptides released by NEURONS as intercellular messengers. Many neuropeptides are also hormones released by non-neuronal cells. Neuropeptide
D009928 Organ Specificity Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen. Tissue Specificity,Organ Specificities,Specificities, Organ,Specificities, Tissue,Specificity, Organ,Specificity, Tissue,Tissue Specificities
D010286 Paraventricular Hypothalamic Nucleus Nucleus in the anterior part of the HYPOTHALAMUS. Hypothalamic Paraventricular Nucleus,Paraventricular Nucleus,Hypothalamic Nucleus, Paraventricular,Nucleus, Hypothalamic Paraventricular,Nucleus, Paraventricular,Nucleus, Paraventricular Hypothalamic,Paraventricular Nucleus, Hypothalamic
D004302 Dorsomedial Hypothalamic Nucleus An aggregation of cells in the middle hypothalamus dorsal to the ventromedial nucleus and bordering the THIRD VENTRICLE. Hypothalamic Nucleus, Dorsomedial,Nucleus, Dorsomedial Hypothalamic
D004435 Eating The consumption of edible substances. Dietary Intake,Feed Intake,Food Intake,Macronutrient Intake,Micronutrient Intake,Nutrient Intake,Nutritional Intake,Ingestion,Dietary Intakes,Feed Intakes,Intake, Dietary,Intake, Feed,Intake, Food,Intake, Macronutrient,Intake, Micronutrient,Intake, Nutrient,Intake, Nutritional,Macronutrient Intakes,Micronutrient Intakes,Nutrient Intakes,Nutritional Intakes
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001069 Appetite Regulation Physiologic mechanisms which regulate or control the appetite and food intake. Food Intake Regulation,Intake Regulation, Food,Regulation, Appetite,Regulation, Food Intake,Appetite Regulations,Food Intake Regulations,Intake Regulations, Food,Regulations, Appetite,Regulations, Food Intake
D015398 Signal Transduction The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway. Cell Signaling,Receptor-Mediated Signal Transduction,Signal Pathways,Receptor Mediated Signal Transduction,Signal Transduction Pathways,Signal Transduction Systems,Pathway, Signal,Pathway, Signal Transduction,Pathways, Signal,Pathways, Signal Transduction,Receptor-Mediated Signal Transductions,Signal Pathway,Signal Transduction Pathway,Signal Transduction System,Signal Transduction, Receptor-Mediated,Signal Transductions,Signal Transductions, Receptor-Mediated,System, Signal Transduction,Systems, Signal Transduction,Transduction, Signal,Transductions, Signal

Related Publications

L J Seal, and C J Small, and W S Dhillo, and S A Stanley, and C R Abbott, and M A Ghatei, and S R Bloom
Hypothalamic dorsomedial nucleus neurons innervate thyrotropin-releasing hormone-synthesizing neurons in the paraventricular nucleus.
February 2001, Brain research,
L J Seal, and C J Small, and W S Dhillo, and S A Stanley, and C R Abbott, and M A Ghatei, and S R Bloom
Gastric motility and food intake in rats after lesions of hypothalamic paraventricular nucleus.
July 1992, The American journal of physiology,
L J Seal, and C J Small, and W S Dhillo, and S A Stanley, and C R Abbott, and M A Ghatei, and S R Bloom
Galanin-like peptide stimulates food intake via activation of neuropeptide Y neurons in the hypothalamic dorsomedial nucleus of the rat.
April 2006, Endocrinology,
L J Seal, and C J Small, and W S Dhillo, and S A Stanley, and C R Abbott, and M A Ghatei, and S R Bloom
Lesion of central part of the dorsomedial nucleus alters vasopressin but not corticotropin releasing hormone mRNA levels in rat hypothalamic paraventricular nucleus.
December 2001, General physiology and biophysics,
L J Seal, and C J Small, and W S Dhillo, and S A Stanley, and C R Abbott, and M A Ghatei, and S R Bloom
GLP-2 decreases food intake in the dorsomedial hypothalamic nucleus (DMH) through Exendin (9-39) in male Sprague-Dawley (SD) rats.
February 2021, Physiology & behavior,
L J Seal, and C J Small, and W S Dhillo, and S A Stanley, and C R Abbott, and M A Ghatei, and S R Bloom
PRL-releasing peptide reduces food intake and may mediate satiety signaling.
February 2002, Endocrinology,
L J Seal, and C J Small, and W S Dhillo, and S A Stanley, and C R Abbott, and M A Ghatei, and S R Bloom
Deficits in the control of food intake after hypothalamic paraventricular nucleus lesions.
December 1985, Physiology & behavior,
L J Seal, and C J Small, and W S Dhillo, and S A Stanley, and C R Abbott, and M A Ghatei, and S R Bloom
Stimulation of the hypothalamic arcuate nucleus increases brown adipose tissue nerve activity via hypothalamic paraventricular and dorsomedial nuclei.
August 2016, American journal of physiology. Heart and circulatory physiology,
L J Seal, and C J Small, and W S Dhillo, and S A Stanley, and C R Abbott, and M A Ghatei, and S R Bloom
Hypothalamic paraventricular nucleus lesions do not prevent anorectic effect of exercise in male rats.
September 1990, The American journal of physiology,
L J Seal, and C J Small, and W S Dhillo, and S A Stanley, and C R Abbott, and M A Ghatei, and S R Bloom
Hypothalamic paraventricular nucleus injections of urocortin alter food intake and respiratory quotient.
October 2001, Brain research,
Copied contents to your clipboard!