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OBJECTIVE To identify features of major salivary gland cancers that are prognostic for disease-free survival. METHODS A retrospective study of 78 patients with major salivary gland cancer (64 parotid and 14 submandibular gland) who underwent surgery for definitive treatment from 1976 to 1996. A select group of patients also received adjuvant radiation (56%) and/or chemotherapy (13%). METHODS Clinical and pathological risk factors were obtained from patients' charts and pathology reports. Age, gender, tumor site, T-stage, facial paralysis, histologic neck involvement, perineural invasion, and cancer grade were analyzed with respect to disease-free survival. The role of adjuvant treatment in terms of clinical outcome was also investigated. RESULTS In our series, the 5-year disease-free survival was 65%. Examining clinical and histologic features one at a time, we found poorer prognosis was associated with submandibular tumors compared with parotid (P =.02), higher T-stage (P =.001), positive cervical nodes (P <.001), perineural invasion (P =.002), and high-grade or adenoid cystic tumors (P =.002). A multivariable analysis indicated that positive lymph nodes (P =.07) and perineural invasion (P =.03) were important histologic predictors of shorter disease-free survival. Receipt of both adjuvant radiation and cisplatin-based chemotherapy (P =.05) was an independent predictor of longer disease-free survival. CONCLUSIONS Our study indicated that the presence of positive lymph nodes and perineural invasion is important independent predictors of disease-free survival. Our limited data also suggest that adjuvant chemotherapy and radiation therapy may improve disease-free survival.
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H Korkmaz, and
G H Yoo, and
V Adsay, and
T Y Shibuya, and
J Abrams, and
J R Jacobs
January 1995,
Head & neck,
E Hocwald, and
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G H Yoo, and
V Adsay, and
T Y Shibuya, and
J Abrams, and
J R Jacobs
October 1986,
The Laryngoscope,
E Hocwald, and
H Korkmaz, and
G H Yoo, and
V Adsay, and
T Y Shibuya, and
J Abrams, and
J R Jacobs
August 2015,
Oral oncology,
E Hocwald, and
H Korkmaz, and
G H Yoo, and
V Adsay, and
T Y Shibuya, and
J Abrams, and
J R Jacobs
January 2004,
Surgical oncology clinics of North America,
E Hocwald, and
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G H Yoo, and
V Adsay, and
T Y Shibuya, and
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January 1998,
Acta oncologica (Stockholm, Sweden),
E Hocwald, and
H Korkmaz, and
G H Yoo, and
V Adsay, and
T Y Shibuya, and
J Abrams, and
J R Jacobs
September 2025,
Japanese journal of clinical oncology,
E Hocwald, and
H Korkmaz, and
G H Yoo, and
V Adsay, and
T Y Shibuya, and
J Abrams, and
J R Jacobs
March 2016,
Oral oncology,
E Hocwald, and
H Korkmaz, and
G H Yoo, and
V Adsay, and
T Y Shibuya, and
J Abrams, and
J R Jacobs
March 2024,
Oral diseases,
E Hocwald, and
H Korkmaz, and
G H Yoo, and
V Adsay, and
T Y Shibuya, and
J Abrams, and
J R Jacobs
July 2017,
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons,
E Hocwald, and
H Korkmaz, and
G H Yoo, and
V Adsay, and
T Y Shibuya, and
J Abrams, and
J R Jacobs
June 2005,
Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale,
