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Clinical use of profound hypothermia and total circulatory arrest has been accompanied by occasional postoperative neurological abnormalities. In a series of infant baboons, surface cooling to 32 degrees C (brain) followed by perfusion cooling by cardiopulmonary bypass with a membrane oxygenator and heat exchanger to 18 degrees C was carried out, after which the circulation was stopped for 30 minutes. The animal was rewarmed to 35 degrees C. Marked alterations in the regional cerebral circulation were observed during perfusion cooling and rewarming. Regional cerebral ischemia was negatively correlated with jugular outflow (total cerebral blood flow) during rewarming, while regional hyperemia showed positive correlation both following perfusion cooling and after rewarming. A higher degree of ischemia in brain ischemic samples was found during rewarming than during cooling. These alterations in regional cerebral perfusion were associated with lactacidosis and hyperglycemia after rewarming, and may be considered potentially responsible for posthypothermic cerebral dysfunction.
M Aoyagi, and
A H Flasterstein, and
J Barnette, and
L V Koch, and
J N Ross, and
J H Kennedy
September 1961,
The Journal of surgical research,
M Aoyagi, and
A H Flasterstein, and
J Barnette, and
L V Koch, and
J N Ross, and
J H Kennedy
September 1992,
The Annals of thoracic surgery,
M Aoyagi, and
A H Flasterstein, and
J Barnette, and
L V Koch, and
J N Ross, and
J H Kennedy
June 1996,
No shinkei geka. Neurological surgery,
M Aoyagi, and
A H Flasterstein, and
J Barnette, and
L V Koch, and
J N Ross, and
J H Kennedy
June 1993,
The Annals of thoracic surgery,
M Aoyagi, and
A H Flasterstein, and
J Barnette, and
L V Koch, and
J N Ross, and
J H Kennedy
May 1995,
The Annals of thoracic surgery,
M Aoyagi, and
A H Flasterstein, and
J Barnette, and
L V Koch, and
J N Ross, and
J H Kennedy
March 1964,
Archives internationales de physiologie et de biochimie,
M Aoyagi, and
A H Flasterstein, and
J Barnette, and
L V Koch, and
J N Ross, and
J H Kennedy
January 1975,
Bibliotheca haematologica,
M Aoyagi, and
A H Flasterstein, and
J Barnette, and
L V Koch, and
J N Ross, and
J H Kennedy
January 2000,
Lancet (London, England),
M Aoyagi, and
A H Flasterstein, and
J Barnette, and
L V Koch, and
J N Ross, and
J H Kennedy
August 1994,
The Annals of thoracic surgery,
M Aoyagi, and
A H Flasterstein, and
J Barnette, and
L V Koch, and
J N Ross, and
J H Kennedy
November 1968,
The Journal of thoracic and cardiovascular surgery,
