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Low plasma renin activity (PRA) has been reported in patients with long-term diabetes mellitus complicated by hypertension and nephropathy. We have assayed PRA in twelve normal subjects and in eight age- and sex-matched juvenile diabetics of greater than twelve years' duration without hypertension and nephropathy under control conditions and following stimulation with diazoxide. During control conditions PRA did not decrease with time in the diabetics as it did in the normals. Following diazoxide infusion, PRA increased in both groups, and although the levels were often higher in diabetics than in normals, the mean differences were not statistically significant. The findings are consistent with the suggestion that PRA is normal or possibly elevated in clinically uncomplicated insulin-dependent diabetes mellitus and decreases with establishment of hypertension and nephropathy.
V V Gossain, and
E E Werk, and
L J Sholiton, and
L Srivastava, and
H C Knowles
March 1979,
Clinical science (London, England : 1979),
V V Gossain, and
E E Werk, and
L J Sholiton, and
L Srivastava, and
H C Knowles
October 1967,
Annals of internal medicine,
V V Gossain, and
E E Werk, and
L J Sholiton, and
L Srivastava, and
H C Knowles
February 1974,
Nihon Naibunpi Gakkai zasshi,
V V Gossain, and
E E Werk, and
L J Sholiton, and
L Srivastava, and
H C Knowles
October 1976,
Diabetes,
V V Gossain, and
E E Werk, and
L J Sholiton, and
L Srivastava, and
H C Knowles
November 1981,
The Journal of clinical endocrinology and metabolism,
V V Gossain, and
E E Werk, and
L J Sholiton, and
L Srivastava, and
H C Knowles
January 1978,
Hormone research,
V V Gossain, and
E E Werk, and
L J Sholiton, and
L Srivastava, and
H C Knowles
January 1988,
Child nephrology and urology,
V V Gossain, and
E E Werk, and
L J Sholiton, and
L Srivastava, and
H C Knowles
August 1981,
Kidney international,
V V Gossain, and
E E Werk, and
L J Sholiton, and
L Srivastava, and
H C Knowles
January 1989,
Diabete & metabolisme,
V V Gossain, and
E E Werk, and
L J Sholiton, and
L Srivastava, and
H C Knowles
December 1986,
Fortschritte der Medizin,
