Analyzed were quantitative literary data on the effects of acute alcohol intoxication on performance. Reviewed were impacts of various doses of alcohol on the psychophysiological parameters and intricate sensorimotor functions of flying human operator. Alcohol was found to be unfavorable to the vestibular function and, therefore, predisposing to traffic and flight accidents. Hence, the alcohol CNS effects give rise to behavioral and psychophysiological disturbances. The psychophysiological disturbances are impaired concentration and dynamic visual function as a whole, deteriorated light differentiation ability and information perception, short-term amnesia, altered alertness and block, and associated lack of self-criticism and self-control.