-transparent.png){kind=logo}
OBJECTIVE To investigate whether the suppression of CFU-GM is caused directly by human cytomegalovirus(HCMV). METHODS The effect of HCMV AD 169 strain on CFU-GM growth was assayed in vitro and HCMV AD 169 DNA in CFU-GM was detected by in situ PCR(ISPCR). RESULTS Significant inhibition of CFU-GM was observed when HCMV AD 169 containing fluid was diluted to 2 x 10(5) pfu/ml and 2 x 10(6) pfu/ml (P < 0.01). The suppression was in a dose-dependent fashion. HCMV AD 169-DNA was detected by ISPCR on the nuclear of CFU-GM. CONCLUSIONS HCMV might cause suppression of CFU-GM growth by direct infection.
Related Publications
W Xiong, and
Z He, and
Q Wang
November 1981,
Blood,
W Xiong, and
Z He, and
Q Wang
January 1987,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
W Xiong, and
Z He, and
Q Wang
June 2001,
Zhongguo shi yan xue ye xue za zhi,
W Xiong, and
Z He, and
Q Wang
January 1992,
Fundamental & clinical pharmacology,
W Xiong, and
Z He, and
Q Wang
January 1989,
Cancer chemotherapy and pharmacology,
W Xiong, and
Z He, and
Q Wang
July 1982,
The Journal of laboratory and clinical medicine,
W Xiong, and
Z He, and
Q Wang
January 1999,
Intervirology,
W Xiong, and
Z He, and
Q Wang
August 1986,
Radiation research,
W Xiong, and
Z He, and
Q Wang
December 1994,
Proceedings of the National Academy of Sciences of the United States of America,
W Xiong, and
Z He, and
Q Wang
October 1986,
British journal of cancer,
