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This report presents experimental observations indicating the presence of an inhibitory activity in cystic fibrosis (CF) serum which impairs phagocytosis of Pseudomonas aeruginosa by rabbit as well as human alveolar macrophages. Of the 49 patient serum samples studied, 40 consistently showed greater than or equal to 60% inhibition, 3 showed no inhibition and 6 were in the range of 20-60% inhibition of Pseudomonas phagocytosis. In parallel studies, the phagocytosis of S. aureus and S. marcescens was found not to be inhibited by CF serum. Mixing of CF serum with normal serum could not overcome the inhibitory effect, indicating the presence of an inhibitory factor rather than the lack of a necessary component. The inhibitory activity is not lost upon exposure of serum to glass, upon freezing the serum once, or upon heating at 56 degrees C for 30 minutes.
M J Thomassen, and
B Boxerbaum, and
C A Demko, and
P J Kuchenbrod, and
D G Dearborn, and
R E Wood
November 1983,
Nihon Kyobu Shikkan Gakkai zasshi,
M J Thomassen, and
B Boxerbaum, and
C A Demko, and
P J Kuchenbrod, and
D G Dearborn, and
R E Wood
October 1973,
The American review of respiratory disease,
M J Thomassen, and
B Boxerbaum, and
C A Demko, and
P J Kuchenbrod, and
D G Dearborn, and
R E Wood
March 1974,
The American review of respiratory disease,
M J Thomassen, and
B Boxerbaum, and
C A Demko, and
P J Kuchenbrod, and
D G Dearborn, and
R E Wood
June 1980,
The Journal of laboratory and clinical medicine,
M J Thomassen, and
B Boxerbaum, and
C A Demko, and
P J Kuchenbrod, and
D G Dearborn, and
R E Wood
November 1982,
Infection and immunity,
M J Thomassen, and
B Boxerbaum, and
C A Demko, and
P J Kuchenbrod, and
D G Dearborn, and
R E Wood
April 1979,
Journal of cellular physiology,
M J Thomassen, and
B Boxerbaum, and
C A Demko, and
P J Kuchenbrod, and
D G Dearborn, and
R E Wood
February 1982,
Clinical immunology and immunopathology,
M J Thomassen, and
B Boxerbaum, and
C A Demko, and
P J Kuchenbrod, and
D G Dearborn, and
R E Wood
April 1988,
Praxis und Klinik der Pneumologie,
M J Thomassen, and
B Boxerbaum, and
C A Demko, and
P J Kuchenbrod, and
D G Dearborn, and
R E Wood
July 1973,
Journal of the Reticuloendothelial Society,
M J Thomassen, and
B Boxerbaum, and
C A Demko, and
P J Kuchenbrod, and
D G Dearborn, and
R E Wood
July 1975,
Applied microbiology,
