1. History in Japan of Wirow, the oldest drug available to the general public, is described. The focus is placed on the manufacture's family, the Kyoto headquarters, and their descendants. 2. There are two different views of the history of the first immigrants to Japan, namely Chen Shun Zu or Chen Yan You. In this article, however, these two persons are assumed to be brothers. 3. The brilliant social activities of Chin Soden, the forefather of the resurrection of wirow, as a medical doctor and a man of culture have been verified philologically. 4. It has also been verified that Wirow Ukon, the 9th generation of wirow, was exiled to a remote place. This was because he played kyokumari, violating the rules of kemari imposed by the Asukai family, kemari's supreme ruler. 5. It has been suggested that the wirow family changed their occupation to operating drug stores in their final days, although they started their carreers as medical doctors.