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Male rats maintained with continuous access to levers for intracranial self-stimulation (ICSS), water, and food were subjected to five consecutive daily injections of heroin (5 mg/kg). Rates of lever pressing for ICSS were increased in 8 rats, 2--6 hrs after administration of heroin. Rates of lever pressing for water and food were not significantly changes during this period. Naloxone (5 mg/kg) pretreatment attenuated by 82% the facilitative effect of heroin on ICSS. A second group of 8 rats maintained at reduced ICSS rates failed to show an increase in lever pressing for ICSS with heroin. The facilitative effect of heroin described in this study is consistent with previously reported studies describing the effects of morphine on ICSS.
G F Koob, and
N H Spector, and
J L Meyerhoff
October 1969,
Life sciences,
G F Koob, and
N H Spector, and
J L Meyerhoff
June 1980,
Physiology & behavior,
G F Koob, and
N H Spector, and
J L Meyerhoff
January 1975,
Confinia neurologica,
G F Koob, and
N H Spector, and
J L Meyerhoff
March 1977,
Psychopharmacology,
G F Koob, and
N H Spector, and
J L Meyerhoff
May 1967,
The Journal of physiology,
G F Koob, and
N H Spector, and
J L Meyerhoff
February 1970,
Physiology & behavior,
G F Koob, and
N H Spector, and
J L Meyerhoff
January 1990,
Psychopharmacology,
G F Koob, and
N H Spector, and
J L Meyerhoff
April 1983,
Pharmacology, biochemistry, and behavior,
G F Koob, and
N H Spector, and
J L Meyerhoff
February 1974,
The Quarterly journal of experimental psychology,
G F Koob, and
N H Spector, and
J L Meyerhoff
April 1994,
Laboratory animal science,
