Biomaterial Database

The comparative efficacy of diamphenethide and rafoxanide against fasciola gigantica in sheep. 1975

J K Kadhim

Efficacy of diamphenethide ("Coriban", Burroughs Wellcome) and rafoxanide ("Ranide", Merck Sharpe & Dohme, Ltd.) was evaluated in lambs against 8-week old experimentally induced Fasciola gigantica infection. Results were assessed by the reduction in worm counts at post-mortem examination 8 weeks after treatment. Diamphenethide at a dosage rate of 100 mg/kg body weight was found 99.4 per cent effective. Rafoxanide at a dosage rate of 10 mg/kg body weight showed 98.78 per cent efficacy. Six weeks following treatment, infected animals treated with either drug exhibited significantly greater weight gain than the non-treated infected animals.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D010270	Parasite Egg Count	Determination of parasite eggs in feces.	Count, Parasite Egg,Counts, Parasite Egg,Egg Count, Parasite,Egg Counts, Parasite,Parasite Egg Counts
D011888	Rafoxanide	Veterinary anthelmintic for grazing animals; used to treat fluke, hookworm and other infestations.	Disalan,Flukanide,MK 990,Rafoxanid,Ranide
D003957	Diamfenetide	Anthelmintic. It has been shown to be useful in fasciola infections in sheep.	Diamphenethide,Acemidophen,Coriban,Di-(2-(4-acetamidophenoxy)ethyl) Ether
D005211	Fascioliasis	Liver disease caused by infections with parasitic flukes of the genus FASCIOLA, such as FASCIOLA HEPATICA.	Fasciola Infection,Fasciola Infections,Fascioliases,Infection, Fasciola,Infections, Fasciola
D000083	Acetanilides	Compounds based on N-phenylacetamide, that are similar in structure to 2-PHENYLACETAMIDES. They are precursors of many other compounds. They were formerly used as ANALGESICS and ANTIPYRETICS, but often caused lethal METHEMOGLOBINEMIA.	Acetylanilines,N-Phenylacetamides
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012457	Salicylamides	Amides of salicylic acid.
D012756	Sheep	Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.	Ovis,Sheep, Dall,Dall Sheep,Ovis dalli
D012757	Sheep Diseases	Diseases of domestic and mountain sheep of the genus Ovis.	Ovine Diseases,Disease, Ovine,Disease, Sheep,Diseases, Ovine,Diseases, Sheep,Ovine Disease,Sheep Disease