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The clinical picture of the experimental tick-borne encephalitis, the time course of viremia, the virus content in the central nervous system and the morphological picture were studied in 15 sheep inoculated intracerebrally with viruses isolated in Byelorussia. The two phases of clinical manifestations (febrile-meningeal and neurological stages) were found to be one of the pathogenetic features of the experimental infection due to both virus multiplication and toxico-allergic reactions on the part of the nervous system. This suggests differences in the pathogenesis of clinical manifestations in the general infectious and neurological stages of the acute period of tick-borne encephalitis in man.
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