J. Kodama (1806-1861) and H. Nanba (1791-1859) were the physicians to the chief retainers of the Bizen feudal clan; Mr. Iki and Mr. Hiki. They lived in the same age, but Kodama lived in obscurity all his life, while Nanba spent his life in famous circumstances. Kodama absconded from the Bizen feudal clan and studied Dutch learning at the private school in Nagasaki which had been founded by Dr. Ph. F. von siebold. But on returning to his native shores his superior officers had no regard for his Dutch learning, resulting in his moving to Osaka, where he died. Nanba learned Chinese medicine from Nangai Yoshimasu, obstetrics from Ransai Kagawa, and surgery from Rokujyō Hanaoka and Seishū Hanaoka. On returning to his native shores, Kanagawa, he founded a private school for the study of medicine, Shiseido, and cultivated many physicians by writing medical books extensively. The author described their activity on the basis of new materials.