Biomaterial Database

[The transition of the standards and the test-methods of cocain hydrochloride between JP I (1886) and JP XII (1991)]. 1992

Y Matsumoto, and M Yamada

Higashi Nippon Gakuen University, School of Dentistry, Hokkaido.

In 1886, Japanese pharmacopoeia (JP.I) has been published as the 21st pharmacopoeia in the world, and now we have the twelfth revised Pharmacopoeia (JP.XII) published in 1991. During the period of about one century between JP.I and JP.XII, pharmaceutical science has shown remarkable progress in Japan as well as the U.S.A. and Europe. In this report, we have studied the transition of the standards and the test-methods of cocain hydrochloride between JP.I and JP.XII. The test-methods of cocain hydrochloride were gradually progressed. Since the World War II, JP.VI (1951) has been revised in wide range by adjusting into the U.S.A. XIV (1950) and then, many old tests have been eliminated and new tests have been regulated. For instance, optical-rotation test in JP.VI and assay in JP.VIII (1976) were good examples of how JP has been revised. Recently, many local-anaesthetic medicines have become very popular. So, the clinical market of cocain hydrochloride will not be so wide in the future in the Japanese medical field.

UI	MeSH Term	Description	Entries
D007564	Japan	A country in eastern Asia, island chain between the North Pacific Ocean and the Sea of Japan, east of the Korean Peninsula. The capital is Tokyo.	Bonin Islands
D010602	Pharmacopoeias as Topic	Works about authoritative treatises on drugs and preparations, their description, formulation, analytic composition, physical constants, main chemical properties used in identification, standards for strength, purity, and dosage, chemical tests for determining identity and purity, etc.	Formulary, National,National Formulary,Formularies, National,National Formularies
D003042	Cocaine	An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.	Cocaine HCl,Cocaine Hydrochloride,HCl, Cocaine,Hydrochloride, Cocaine
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D049672	History, 19th Century	Time period from 1801 through 1900 of the common era.	19th Century History,19th Cent. History (Medicine),19th Cent. History of Medicine,19th Cent. Medicine,Historical Events, 19th Century,History of Medicine, 19th Cent.,History, Nineteenth Century,Medical History, 19th Cent.,Medicine, 19th Cent.,19th Cent. Histories (Medicine),19th Century Histories,Cent. Histories, 19th (Medicine),Cent. History, 19th (Medicine),Century Histories, 19th,Century Histories, Nineteenth,Century History, 19th,Century History, Nineteenth,Histories, 19th Cent. (Medicine),Histories, 19th Century,Histories, Nineteenth Century,History, 19th Cent. (Medicine),Nineteenth Century Histories,Nineteenth Century History
D049673	History, 20th Century	Time period from 1901 through 2000 of the common era.	20th Century History,20th Cent. History (Medicine),20th Cent. History of Medicine,20th Cent. Medicine,Historical Events, 20th Century,History of Medicine, 20th Cent.,History, Twentieth Century,Medical History, 20th Cent.,Medicine, 20th Cent.,20th Cent. Histories (Medicine),20th Century Histories,Cent. Histories, 20th (Medicine),Cent. History, 20th (Medicine),Century Histories, 20th,Century Histories, Twentieth,Century History, 20th,Century History, Twentieth,Histories, 20th Cent. (Medicine),Histories, 20th Century,Histories, Twentieth Century,History, 20th Cent. (Medicine),Twentieth Century Histories,Twentieth Century History