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Hemoglobin Fort Gordon, alpha2beta2145 Tyr replaced by Asp (HC2), has been observed in a 20-year-old black male with compensatory erythrocytosis. The variant was readily identified by electrophoresis and chromatography, and comprised about 30% of the red cell hemoglobin. The substitution was identified through analyses of tryptic peptides of various digests of the isolated beta chain. The oxygen affinity of whole blood was increased; two components were observed one of which had a greatly increased affinity for oxygen and a markedly reduced subunit cooperativity. It appears that the Tyr replaced by Asp substitution resembles the Tyr replaced by His substitution in hemoglobin Bethesda (Bunn, H. F. et al. (1972) J. Clin. Invest. 51, 2299-2309; Olson, J. S. and Gibson, G. H. (1972) J Biol. Chem. 247, 3662-3670; Adamson et al. (1972) J. Clin. Invest. 51, 2883-2888) in that both inhibit the quarternary change of the oxy to the deoxy conformation, resulting in greatly altered functional properties. Studies of a few members of the family were negative.
H B Kleckner, and
J B Wilson, and
J G Lindeman, and
P D Stevens, and
G Niazi, and
E Hunter, and
C J Chen, and
T H Huisman
April 1981,
FEBS letters,
H B Kleckner, and
J B Wilson, and
J G Lindeman, and
P D Stevens, and
G Niazi, and
E Hunter, and
C J Chen, and
T H Huisman
January 1981,
Hemoglobin,
H B Kleckner, and
J B Wilson, and
J G Lindeman, and
P D Stevens, and
G Niazi, and
E Hunter, and
C J Chen, and
T H Huisman
January 1981,
Hemoglobin,
H B Kleckner, and
J B Wilson, and
J G Lindeman, and
P D Stevens, and
G Niazi, and
E Hunter, and
C J Chen, and
T H Huisman
August 1975,
FEBS letters,
H B Kleckner, and
J B Wilson, and
J G Lindeman, and
P D Stevens, and
G Niazi, and
E Hunter, and
C J Chen, and
T H Huisman
January 1983,
Hemoglobin,
H B Kleckner, and
J B Wilson, and
J G Lindeman, and
P D Stevens, and
G Niazi, and
E Hunter, and
C J Chen, and
T H Huisman
July 1977,
Biochimica et biophysica acta,
H B Kleckner, and
J B Wilson, and
J G Lindeman, and
P D Stevens, and
G Niazi, and
E Hunter, and
C J Chen, and
T H Huisman
January 1976,
Hemoglobin,
H B Kleckner, and
J B Wilson, and
J G Lindeman, and
P D Stevens, and
G Niazi, and
E Hunter, and
C J Chen, and
T H Huisman
January 1976,
Hemoglobin,
H B Kleckner, and
J B Wilson, and
J G Lindeman, and
P D Stevens, and
G Niazi, and
E Hunter, and
C J Chen, and
T H Huisman
January 1990,
Hemoglobin,
H B Kleckner, and
J B Wilson, and
J G Lindeman, and
P D Stevens, and
G Niazi, and
E Hunter, and
C J Chen, and
T H Huisman
January 1995,
Hemoglobin,
