Biomaterial Database

Dynamic changes in blood solubility of desflurane, isoflurane, and halothane during cardiac surgery. 2001

J X Zhou, and J Liu

Department of Anesthesiology, Fuwai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China. jianxinz@yeah.net

OBJECTIVE To determine an estimate of blood/gas partition coefficients of volatile anesthetics during cardiac surgery. METHODS Descriptive METHODS University hospital METHODS Six adult patients undergoing valvular replacement with hypothermic cardiopulmonary bypass. RESULTS Blood samples were obtained from patients at 6 time points: before induction, at skin incision, at aortic cannulation, at rewarming during bypass, at weaning off bypass, and at skin suture. Measured blood/gas partition coefficients were plotted against corresponding solubilities estimated according to the combined effects of hypothermia and hemodilution. Significant differences were found in blood/gas partition coefficients of the 3 anesthetics at different times during surgery (p < 0.05). Blood/gas partition coefficients at weaning off bypass were the lowest, about 75% of that before anesthetic induction. A direct linear relationship for estimated solubility against measured solubility was found (r2 = 0.94; p < 0.05). CONCLUSIONS Dynamic changes in blood/gas partition coefficients of volatile anesthetics were found during cardiac surgery. They could be estimated by using multiple linear regression equations reflecting the combined effects of hypothermia and hemodilution.

UI	MeSH Term	Description	Entries
D007530	Isoflurane	A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
D008297	Male		Males
D002315	Cardiopulmonary Bypass	Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.	Heart-Lung Bypass,Bypass, Cardiopulmonary,Bypass, Heart-Lung,Bypasses, Cardiopulmonary,Bypasses, Heart-Lung,Cardiopulmonary Bypasses,Heart Lung Bypass,Heart-Lung Bypasses
D006221	Halothane	A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)	1,1,1-Trifluoro-2-Chloro-2-Bromoethane,Fluothane,Ftorotan,Narcotan
D006348	Cardiac Surgical Procedures	Surgery performed on the heart.	Cardiac Surgical Procedure,Heart Surgical Procedure,Heart Surgical Procedures,Procedure, Cardiac Surgical,Procedure, Heart Surgical,Procedures, Cardiac Surgical,Procedures, Heart Surgical,Surgical Procedure, Cardiac,Surgical Procedure, Heart,Surgical Procedures, Cardiac,Surgical Procedures, Heart
D006438	Hemodilution	Reduction of blood viscosity usually by the addition of cell free solutions. Used clinically (1) in states of impaired microcirculation, (2) for replacement of intraoperative blood loss without homologous blood transfusion, and (3) in cardiopulmonary bypass and hypothermia.	Hemodilutions
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077335	Desflurane	A fluorinated ether that is used as a volatile anesthetic for maintenance of general anesthesia.	1,2,2,2-Tetrafluoroethyl difluoromethyl ether,I 653,I-653,I653,Suprane
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D012995	Solubility	The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Solubilities