BIOMAT Database Logo BIOMAT Database Logo

Synthesis of new derivatives of bis-3(4-R-delta2-1,2,4-triazolin-5-one). 2001

A Pachuta-Stec, and M Dobosz
Department of Organic Chemistry, Faculty of Pharmacy, Medical University, Lublin, Poland.

In the reaction of oxalic acid hydrazide with isocyanates, new derivatives of semicarbazide were obtained [I-XII]. Cyclization of these derivatives with an aqueous 2% sodium hydroxide led to formation of new derivatives of delta2-1,2,4-triazolin-5-one [XIII-XXIV].

UI MeSH Term Description Entries
D007202 Indicators and Reagents Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499) Indicator,Reagent,Reagents,Indicators,Reagents and Indicators
D009682 Magnetic Resonance Spectroscopy Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING). In Vivo NMR Spectroscopy,MR Spectroscopy,Magnetic Resonance,NMR Spectroscopy,NMR Spectroscopy, In Vivo,Nuclear Magnetic Resonance,Spectroscopy, Magnetic Resonance,Spectroscopy, NMR,Spectroscopy, Nuclear Magnetic Resonance,Magnetic Resonance Spectroscopies,Magnetic Resonance, Nuclear,NMR Spectroscopies,Resonance Spectroscopy, Magnetic,Resonance, Magnetic,Resonance, Nuclear Magnetic,Spectroscopies, NMR,Spectroscopy, MR
D012663 Semicarbazides Derivatives of UREA where one of the amino groups is replaced with hydrazine.
D014230 Triazoles Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3. Triazole
D017953 Isocyanates Organic compounds that contain the -NCO radical. Isocyanate
D019815 Oxalic Acid A strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted in the urine. It is used as an analytical reagent and general reducing agent. Aluminum Oxalate,Ammonium Oxalate,Chromium (2+) Oxalate,Chromium (3+) Oxalate (3:2),Chromium Oxalate,Diammonium Oxalate,Dilithium Oxalate,Dipotassium Oxalate,Disodium Oxalate,Ferric Oxalate,Iron (2+) Oxalate (1:1),Iron (3+) Oxalate,Iron Oxalate,Magnesium Oxalate,Magnesium Oxalate (1:1),Manganese (2+) Oxalate (1:1),Monoammonium Oxalate,Monohydrogen Monopotassium Oxalate,Monopotassium Oxalate,Monosodium Oxalate,Potassium Chromium Oxalate,Potassium Oxalate,Potassium Oxalate (2:1),Sodium Oxalate,Acid, Oxalic,Oxalate, Aluminum,Oxalate, Chromium,Oxalate, Diammonium,Oxalate, Dilithium,Oxalate, Dipotassium,Oxalate, Disodium,Oxalate, Ferric,Oxalate, Iron,Oxalate, Magnesium,Oxalate, Monoammonium,Oxalate, Monohydrogen Monopotassium,Oxalate, Monopotassium,Oxalate, Monosodium,Oxalate, Potassium,Oxalate, Potassium Chromium,Oxalate, Sodium

Related Publications

A Pachuta-Stec, and M Dobosz
Synthesis of 1-(3-aminopropyl)-4-phenyl-1,2,4-triazolin-5-one and 1-(3-aminopropyl)-3,4-diphenyl-1,2,4-triazolin-5-one.
January 2001, Acta poloniae pharmaceutica,
A Pachuta-Stec, and M Dobosz
Synthesis and some pharmacological properties of 3-(4-phenyl-5-oxo-1,2,4-triazolin-1-ylmethyl)-1,2,4-triazolin-5-thione derivatives.
January 2002, Acta poloniae pharmaceutica,
A Pachuta-Stec, and M Dobosz
Synthesis of aminomethyl derivatives of 4-phenyl-1,2,4-triazolin-5-one-1-acetic acid amide and 3,4-diphenyl-1,2,4-triazolin-5-one-1-acetic acid amide.
January 2000, Acta poloniae pharmaceutica,
A Pachuta-Stec, and M Dobosz
Synthesis and biological action of 1-aminomethyl derivatives of 3-R-4-phenyl-delta2-1,2,4-triazoline-5-thione.
January 2005, Acta poloniae pharmaceutica,
A Pachuta-Stec, and M Dobosz
Synthesis and biological action of 3-R-4-substituted-delta2-1,2,4-triazoline-5-thione.
January 2003, Acta poloniae pharmaceutica,
A Pachuta-Stec, and M Dobosz
Synthesis, characterization and in vitro anticancer evaluation of novel 1,2,4-triazolin-3-one derivatives.
April 2013, European journal of medicinal chemistry,
A Pachuta-Stec, and M Dobosz
Ion kinetic energy spectra of 3-phenyl-delta2-1,2,4-oxadiazolin-5-one and some 4-alkyl derivatives.
May 1977, Bollettino chimico farmaceutico,
A Pachuta-Stec, and M Dobosz
Crystal structure of 4-amino-1-benzyl-1,2,4-triazolin-5-one.
October 2014, Acta crystallographica. Section E, Structure reports online,
A Pachuta-Stec, and M Dobosz
[Synthesis of 1-aroyl-4H(R)-thiosemicarbazides, the corresponding 5-aryl 4H(R)-1,2,4-triazolin-3-thiones and some derivatives of pharmaceutical interest].
March 1981, Il Farmaco; edizione scientifica,
A Pachuta-Stec, and M Dobosz
Pharmacological evaluation of delta2, 1,2,4-triazolin-5-one [1,3(4-m-chlorophenyl-1-piperazinyl)-propyl]-3,4-diethyl-hydrochloride (Etoperidone), a new potential antidepressant drug.
January 1979, Arzneimittel-Forschung,
Copied contents to your clipboard!