Biomaterial Database

Effects of oral and intramuscular carbaryl administrations on repeated chain acquisition in monkeys. 1979

W K Anger, and J V Setzer

A type of learning task was utilized to determine the effective dose of carbaryl on Macaca fascicularis for both oral and in routes of administration. Monkeys were required to press four buttons in a set order; the order was changed daily. A baseline reversal design was utilized to test all animals several times at each concentration. The im carbaryl injections resulted in consistent, statistically reliable decrements in total session time and increases in errors at 5 and 10 mg/kg for the 4 animals in this section of the experiment, but produced no change in performance at 1 mg/kg. Errors increased in 3 of 4 monkeys after 3 mg/kg injections. Oral doses as high as 50 mg/kg were not consistently effective in changing performance on the task in any of 5 animals included in this section of the experiment. Some support was given to the suggestion that monkeys are more tolerant of carbaryl than are rats. These are the first reported effects (other than the LD50) of carbaryl in monkeys.

UI	MeSH Term	Description	Entries
D007273	Injections, Intramuscular	Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.	Intramuscular Injections,Injection, Intramuscular,Intramuscular Injection
D008252	Macaca fascicularis	A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula.	Burmese Long-Tailed Macaque,Crab-Eating Monkey,Cynomolgus Monkey,M. f. aurea,M. fascicularis,Macaca fascicularis aurea,Monkey, Crab-Eating,Monkey, Cynomolgus,Crab-Eating Macaque,Burmese Long Tailed Macaque,Crab Eating Macaque,Crab Eating Monkey,Crab-Eating Macaques,Crab-Eating Monkeys,Cynomolgus Monkeys,Long-Tailed Macaque, Burmese,Macaque, Burmese Long-Tailed,Macaque, Crab-Eating,Monkey, Crab Eating
D008297	Male		Males
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000882	Haplorhini	A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).	Anthropoidea,Monkeys,Anthropoids,Monkey
D012691	Serial Learning	Learning to make a series of responses in exact order.	Learning, Serial,Learnings, Serial,Serial Learnings
D012721	Carbaryl	A carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries.	1-Naphthyl-N-methylcarbamate,Antigale,Carbaril,Carbaryl, Manganese (2+) Salt,Carbaryl, Nickel (2+) Salt,Carbyl,Carylderm,Concentrat VO 18,Dog-Net Insecticide Poudre,Fido's Free-Itch,G-Wizz,Joseph Lyddy,Océcoxil,Poudre insecticide Moureau,Poudre insecticide Vetoquinol,Poutic,Sevin,Skatta Tick Flea Louse Powder,Sépou,Tigal,Dog Net Insecticide Poudre,DogNet Insecticide Poudre,Fido's Free Itch,Fido's FreeItch,G Wizz,GWizz,Lyddy, Joseph,Moureau, Poudre insecticide,VO 18, Concentrat,Vetoquinol, Poudre insecticide,insecticide Moureau, Poudre,insecticide Vetoquinol, Poudre
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor