-transparent.png){kind=logo}
We have demonstrated previously that exogenously expressed Brn-3a is capable of protecting neurons of the peripheral nervous system against apoptosis. In these previous studies Brn-3a showed a degree of neuronal sub-type specificity, in that while it could promote survival in NGF-dependent sensory neurons, no effect was observed in NGF-dependent neurons of the sympathetic nervous system. In this report, we show that Brn-3a delivered using a herpes simplex virus is capable of protecting cultures of rat cerebrocortical neurons of the central nervous system against two types of cell death stimuli, including glutamate neurotoxicity. Hence the protective effect of Brn-3a is not confined to neurons of the peripheral nervous system but can also occur in neurons of the CNS.
M D Smith, and
E A Ensor, and
R A Kinloch, and
D S Latchman
June 1993,
Nucleic acids research,
M D Smith, and
E A Ensor, and
R A Kinloch, and
D S Latchman
November 1998,
The international journal of biochemistry & cell biology,
M D Smith, and
E A Ensor, and
R A Kinloch, and
D S Latchman
July 1999,
Development (Cambridge, England),
M D Smith, and
E A Ensor, and
R A Kinloch, and
D S Latchman
December 1993,
Nucleic acids research,
M D Smith, and
E A Ensor, and
R A Kinloch, and
D S Latchman
January 2006,
Oncogene,
M D Smith, and
E A Ensor, and
R A Kinloch, and
D S Latchman
May 1999,
The Journal of biological chemistry,
M D Smith, and
E A Ensor, and
R A Kinloch, and
D S Latchman
December 2002,
Neuroscience letters,
M D Smith, and
E A Ensor, and
R A Kinloch, and
D S Latchman
September 2008,
Cell stress & chaperones,
M D Smith, and
E A Ensor, and
R A Kinloch, and
D S Latchman
June 1997,
International journal of oncology,
M D Smith, and
E A Ensor, and
R A Kinloch, and
D S Latchman
November 2007,
Wei sheng yan jiu = Journal of hygiene research,
