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In this review, the neuroprotective actions of testosterone on three different populations of injured rat peripheral motoneurons, i.e. facial (FMN), spinal (SMN) and pudendal (PMN), will be discussed. We have extrapolated concepts from the neuroendocrine field regarding the trophic effects of gonadal steroids on target neural tissue to the nerve regeneration field. Exogenous administration of testosterone immediately after nerve injury impacts positively on functional recovery through actions mediated by the androgen receptor. The mechanism by which steroidal enhancement of the regenerative properties of injured motoneurons occurs may involve pre-existing androgen receptors, heat shock proteins, and modulation of the cellular stress response.
K J Jones, and
T J Brown, and
M Damaser
January 2010,
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K J Jones, and
T J Brown, and
M Damaser
April 2006,
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K J Jones, and
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M Damaser
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Stroke,
K J Jones, and
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M Damaser
March 1985,
Experientia,
K J Jones, and
T J Brown, and
M Damaser
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The Journal of pharmacology and experimental therapeutics,
K J Jones, and
T J Brown, and
M Damaser
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Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
K J Jones, and
T J Brown, and
M Damaser
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Psychoneuroendocrinology,
K J Jones, and
T J Brown, and
M Damaser
January 2006,
Journal of molecular neuroscience : MN,
K J Jones, and
T J Brown, and
M Damaser
July 2009,
Frontiers in neuroendocrinology,
K J Jones, and
T J Brown, and
M Damaser
June 1986,
Pediatric dermatology,
