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OBJECTIVE Cyclin D1 is known to play important roles in the G1/S check-point of the cell cycle. We investigated the correlation between cyclin D1 overexpression and clinical characteristics to clarify its prognostic significance in patients with esophageal cancer. METHODS From 1991 to 1998, cyclin D1 was investigated in esophageal cancers from 86 patients who underwent esophagectomy. Overexpression of cyclin D1 was demonstrated using an immunohistochemical method. RESULTS Overexpression of cyclin D1 was found in 23 (26.7%) of 86 cases. Overexpression of cyclin D1 correlated with lymph node metastasis (P = 0.0083) and lymphatic vessel invasion (P = 0.018). Cyclin D1 overexpression may indicate resistance to chemotherapy. The patients with cyclin D1 overexpression had a significantly lower survival rate than those without overexpression (P = 0.013). The multivariate analysis revealed cyclin D1 overexpression to be an important prognostic factor in patients with esophageal cancer. CONCLUSIONS Immunohistochemical examination of cyclin D1 expression may provide important prognostic information in univariate and multivariate analysis and may be necessary for determining therapeutic strategies for esophageal cancer.
S Nagasawa, and
M Onda, and
K Sasajima, and
H Makino, and
K Yamashita, and
K Takubo, and
M Miyashita
June 1998,
The Journal of laryngology and otology,
S Nagasawa, and
M Onda, and
K Sasajima, and
H Makino, and
K Yamashita, and
K Takubo, and
M Miyashita
January 2012,
Cancer biomarkers : section A of Disease markers,
S Nagasawa, and
M Onda, and
K Sasajima, and
H Makino, and
K Yamashita, and
K Takubo, and
M Miyashita
April 2011,
The Indian journal of medical research,
S Nagasawa, and
M Onda, and
K Sasajima, and
H Makino, and
K Yamashita, and
K Takubo, and
M Miyashita
January 2023,
Northern clinics of Istanbul,
S Nagasawa, and
M Onda, and
K Sasajima, and
H Makino, and
K Yamashita, and
K Takubo, and
M Miyashita
April 2001,
Liver,
S Nagasawa, and
M Onda, and
K Sasajima, and
H Makino, and
K Yamashita, and
K Takubo, and
M Miyashita
February 2000,
International journal of oncology,
S Nagasawa, and
M Onda, and
K Sasajima, and
H Makino, and
K Yamashita, and
K Takubo, and
M Miyashita
January 1997,
Japanese journal of cancer research : Gann,
S Nagasawa, and
M Onda, and
K Sasajima, and
H Makino, and
K Yamashita, and
K Takubo, and
M Miyashita
October 1996,
Clinical cancer research : an official journal of the American Association for Cancer Research,
S Nagasawa, and
M Onda, and
K Sasajima, and
H Makino, and
K Yamashita, and
K Takubo, and
M Miyashita
February 1999,
Virchows Archiv : an international journal of pathology,
S Nagasawa, and
M Onda, and
K Sasajima, and
H Makino, and
K Yamashita, and
K Takubo, and
M Miyashita
January 2018,
OncoTargets and therapy,
