Biomaterial Database

Effects of intergeniculate leaflet lesions on circadian rhythms in the mouse. 2002

Marian H Lewandowski, and Artur Usarek

Department of Animal Physiology, Institute of Zoology, Jagiellonian University, R. Ingardena St. 6, 30060 Cracow, Poland. lew@zuk.iz.uj.edu.pl

We investigated effects of bilateral electrolytic intergeniculate leaflet (IGL) lesions (IGLX) on circadian rhythms of the wheel-running activity in mice kept under constant darkness conditions (DD). As a result of complete bilateral IGL lesions, the period of a free-running rhythm was lengthened by ca. 45 min in comparison with a pre-operational one. The present findings confirm results obtained previously with other animals. However, for the first time locomotor activity levels were precisely assessed in mice (the number of wheel revolutions/day) before and after IGL lesions. A computer analysis of data showed a considerable decrease in that activity (by 68% on an average) in mice with complete bilateral IGL lesions in comparison with IGL-non-lesioned individuals. The obtained results show that also in mice IGL constitutes an anatomically important element of the mechanism of a circadian time-keeping system, which mediates the transfer of non-photic information to the suprachiasmatic nuclei (SCN) by modulating their activity.

UI	MeSH Term	Description	Entries
D009043	Motor Activity	Body movements of a human or an animal as a behavioral phenomenon.	Activities, Motor,Activity, Motor,Motor Activities
D002940	Circadian Rhythm	The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli.	Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D003624	Darkness	The absence of light.	Darknesses
D005829	Geniculate Bodies	Part of the DIENCEPHALON inferior to the caudal end of the dorsal THALAMUS. Includes the lateral geniculate body which relays visual impulses from the OPTIC TRACT to the calcarine cortex, and the medial geniculate body which relays auditory impulses from the lateral lemniscus to the AUDITORY CORTEX.	Lateral Geniculate Body,Medial Geniculate Body,Metathalamus,Corpus Geniculatum Mediale,Geniculate Nucleus,Lateral Geniculate Nucleus,Medial Geniculate Complex,Medial Geniculate Nucleus,Nucleus Geniculatus Lateralis Dorsalis,Nucleus Geniculatus Lateralis Pars Dorsalis,Bodies, Geniculate,Complex, Medial Geniculate,Complices, Medial Geniculate,Corpus Geniculatum Mediales,Geniculate Bodies, Lateral,Geniculate Bodies, Medial,Geniculate Body,Geniculate Body, Lateral,Geniculate Body, Medial,Geniculate Complex, Medial,Geniculate Complices, Medial,Geniculate Nucleus, Lateral,Geniculate Nucleus, Medial,Geniculatum Mediale, Corpus,Geniculatum Mediales, Corpus,Lateral Geniculate Bodies,Medial Geniculate Bodies,Medial Geniculate Complices,Mediale, Corpus Geniculatum,Mediales, Corpus Geniculatum,Nucleus, Geniculate,Nucleus, Lateral Geniculate,Nucleus, Medial Geniculate
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus