Total synthesis of indole and dihydroindole alkaloids. VII. The total synthesis of isovelbanamine, velbanamine, cleavamine, 18beta-carbomethoxycleavamine and catharanthine.
1975
J P Kutney, and
F Bylsma
UI
MeSH Term
Description
Entries
D007211
Indoles
Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
D008722
Methods
A series of steps taken in order to conduct research.
Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)
A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS.
January 1974,
Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progres dans la chimie des substances organiques naturelles,