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[Adaptation to hyperthermia and changes in peripheral blood leukocytes in humans]. 2001
L I Andreeva, and
V V Goranchuk, and
E B Shustov, and
A A Boĭkova, and
V S Petrova, and
M K Rzhepetskaia, and
V N Kuznetsov, and
I A Men'shakov, and
B A Margulis, and
P D Shabanov
Russian Military-Medical Academy, St. Petersburg, 194175, Lebedev St., 6, Russia.
Heating humans up to rectal temperature 39.0-39.5 degrees C induces a heat stress and a physiological adaptation. Blood cells were found to produce nitric oxide under these conditions, neutrophiles playing a major role in the process. In our opinion, the HSC 70 takes part in the process of the long cell adaptation augmenting the cells' functional activity. Hyperthermia leads to a massive temporal HSP 72 expression in the blood mononuclears. This expression seems to be due to alterations in the cellular proteins and to oxidative stress.
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