A fat-free liquid diet was formulated to be administered by nasogastric tube as therapy for hyperlipaemia in ponies. The liquid diet provided energy, protein, minerals, trace elements, and vitamins in accordance with the requirements of ponies. As sole source of nutrition, the liquid diet fully counteracted fasting-induced hyperlipaemia in two healthy ponies. The liquid diet was also used in hyperlipaemic patients, but only in combination with conventional therapy, consisting of intravenous administration of glucose, insulin, and heparin. Although no patients were treated with the liquid diet alone, the liquid diet has potential in the treatment of hyperlipaemia - it is easy to prepare and to administer by nasogastric tube and it provides energy and nutrients to counteract the negative energy balance and low nutritional status of patients. Experience is needed with hyperlipaemic patients that are treated with the liquid diet only.