This study compared the attentional effects of object appearances (onsets) and disappearances (offsets) in moderately complex displays. Four experiments showed that onsets produce the inhibition of return (IOR) effect that has been found with simpler displays. In contrast, although offsets did produce inhibitory effects, these effects did not follow the spatial or temporal pattern of IOR. Two further experiments used a very salient object disappearance to determine whether the typical pattern for IOR could be instantiated; it was not. The results indicate that object appearances are more potent perceptual events than object disappearances. In addition, object disappearances have different attentional consequences than object appearances: Disappearances provoke earlier and spatially narrower inhibition. The results are consistent with the view that inhibition serves a functional role in increasing the efficiency of visual search processes.