Biomaterial Database

Functional alteration of brain dopaminergic system in isolated aggressive mice. 2001

T Matsuda, and M Sakaue, and Y Ago, and Y Sakamoto, and Y Koyama, and A Baba

Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, 565-0871 Japan.

The present study examined the effects of social isolation on cortical dopamine (DA) release in vivo and on brain DA receptor functions to study the possible involvement of cortical DA neurons in an antiaggressive effect of the serotonin (5-HT)1A receptor agonist (S)-5-[3-[(1,4-benzodioxan-2-ylmethyl)amino] propoxy]-1,3-benzodioxole HCl (MKC-242). MKC-242 and the DA receptor agonist apomorphine reduced aggressive behavior in isolated mice. MKC-242 increased cortical DA release in vivo in mice, and the effect was antagonized by the 5-HT1A receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide. The basal level of extracellular DA in the frontal cortex was higher in isolated mice than in grouped mice. MKC-242-induced and high K(+)-induced increases in the cortical DA release were less pronounced in isolated mice than in grouped mice. The effect of apomorphine on locomotor activity was more pronounced in isolated mice than in grouped mice. These findings suggest that the isolation stress enhances cortical DA release and the brain DA receptor function and reduces the responses of the dopaminergic terminals to 5-HT1A receptor stimulation and high K(+)-induced depolarization.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009043	Motor Activity	Body movements of a human or an animal as a behavioral phenomenon.	Activities, Motor,Activity, Motor,Motor Activities
D011954	Receptors, Dopamine	Cell-surface proteins that bind dopamine with high affinity and trigger intracellular changes influencing the behavior of cells.	Dopamine Receptors,Dopamine Receptor,Receptor, Dopamine
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D004146	Dioxanes	Compounds that contain the structure 1,4-dioxane.
D004149	Dioxoles
D004298	Dopamine	One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.	Hydroxytyramine,3,4-Dihydroxyphenethylamine,4-(2-Aminoethyl)-1,2-benzenediol,Dopamine Hydrochloride,Intropin,3,4 Dihydroxyphenethylamine,Hydrochloride, Dopamine
D005625	Frontal Lobe	The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.	Brodmann Area 8,Brodmann's Area 8,Frontal Cortex,Frontal Eye Fields,Lobus Frontalis,Supplementary Eye Field,Area 8, Brodmann,Area 8, Brodmann's,Brodmanns Area 8,Cortex, Frontal,Eye Field, Frontal,Eye Field, Supplementary,Eye Fields, Frontal,Frontal Cortices,Frontal Eye Field,Frontal Lobes,Lobe, Frontal,Supplementary Eye Fields
D000374	Aggression	Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.	Aggressions
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia