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Ethacrynic acid infused i.v. in anesthetized dogs after inhibiting sympathetic mechanisms of renin release increased renal blood flow rate (RBF) by 54% and practically abolished autoregulation of RBF; renin release increased from 0.8 +/- 0.9 (mean +/- SEM) to 16.4 +/- 3.7 mug/min (P less than 0.05). Without infusion of ethacrynic acid; constriction of the renal artery to a pressure below the range of autoregulation reduced renovascular resistance markedly and renin release rose to 27.2 +/- 5.5 mug/min (P less than 0.05). During arterial constriction, ethacrynic acid had no additional effect on renovascular resistance or renin release averaging 28.4 +/- 6.7 mug/min. Infusion of ethacrynic acid and saline at control pressure increased sodium excretion to about one-half of the filtrate and reduced rein release which did not, however, return to control. Infusion of hypertonic saline during autoregulated vasodilatation induced by arterial constriction had a similar effect, but again renin release continued to exceed control. We propose that ethacrynic acid increases renin release through a hemodynamic mechanism triggered by afferent arteriolar dilation and inhibits renin release by greatly increasing the delivery of sodium to the distal convoluted tubules.
I Eide, and
E Loyning, and
O Langård, and
F Kiil
July 1981,
Klinische Wochenschrift,
I Eide, and
E Loyning, and
O Langård, and
F Kiil
November 1986,
Kidney international,
I Eide, and
E Loyning, and
O Langård, and
F Kiil
June 1976,
The Journal of physiology,
I Eide, and
E Loyning, and
O Langård, and
F Kiil
February 1971,
The American journal of physiology,
I Eide, and
E Loyning, and
O Langård, and
F Kiil
July 1971,
Minerva medica,
I Eide, and
E Loyning, and
O Langård, and
F Kiil
February 1990,
Hypertension (Dallas, Tex. : 1979),
I Eide, and
E Loyning, and
O Langård, and
F Kiil
December 1976,
Clinical science and molecular medicine. Supplement,
I Eide, and
E Loyning, and
O Langård, and
F Kiil
November 1990,
Kidney international. Supplement,
I Eide, and
E Loyning, and
O Langård, and
F Kiil
June 1974,
Japanese journal of pharmacology,
I Eide, and
E Loyning, and
O Langård, and
F Kiil
May 1976,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
