-transparent.png){kind=logo}
OBJECTIVE To explore the relationship of beta-adrenoreceptor density and function with the condition of patients with essential hypertension. METHODS In the present study, 69 male patients with essential hypertension at different stages were compared with a group of age-matched normotensive controls. beta-adrenoreceptor maximum bound volume (Bmax) in peripheral lymphocytes was measured by 3H-dihydroalprenolol (3 H-DHA) radio ligand binding. beta-adrenoreceptor responsiveness was determined by Salbutamol (injection). RESULTS In patients with essential hypertension at stages I and II, Bmax was significantly higher (P < 0.01 and P < 0.001, respectively) and the chronotropic doses of Salbutamol required to increase the heart rate by 30 beats/min (CD30) were significantly lower (P < 0.01 and P < 0.001, respectively) than in age-matched normotensive control subjects. In patients with essential hypertension at stage III, Bmax was significantly lower and CD30 was significantly higher (both P < 0.01) than those in the age-matched normotensive control subjects. Bmax was significantly higher and CD30 was significantly lower (both P < 0.001) in patients with essential hypertension and with left ventricular hypertrophy (LVH) than that in patients with essential hypertension but without LVH. In patients with essential hypertension and heart failure, Bmax was significantly lower and CD30 was significantly higher (both P < 0.001) than those in patients with essential hypertension without heart failure. CONCLUSIONS The changes of beta-adrenoreceptor density and function were related to hypertension, hypertension complicated with ventricular hypertrophy, and heart failure. They may be viewed as indexes of the condition in the patients with essential hypertension.
Y Peng, and
S Ma, and
S Zhang, and
Y Li, and
L Yang, and
S Bian
January 1999,
Terapevticheskii arkhiv,
Y Peng, and
S Ma, and
S Zhang, and
Y Li, and
L Yang, and
S Bian
January 1999,
Terapevticheskii arkhiv,
Y Peng, and
S Ma, and
S Zhang, and
Y Li, and
L Yang, and
S Bian
August 1979,
Archives of internal medicine,
Y Peng, and
S Ma, and
S Zhang, and
Y Li, and
L Yang, and
S Bian
April 1992,
Zhonghua xin xue guan bing za zhi,
Y Peng, and
S Ma, and
S Zhang, and
Y Li, and
L Yang, and
S Bian
November 2003,
Japanese heart journal,
Y Peng, and
S Ma, and
S Zhang, and
Y Li, and
L Yang, and
S Bian
January 2001,
Likars'ka sprava,
Y Peng, and
S Ma, and
S Zhang, and
Y Li, and
L Yang, and
S Bian
January 1987,
Kardiologia polska,
Y Peng, and
S Ma, and
S Zhang, and
Y Li, and
L Yang, and
S Bian
April 1985,
Circulation,
Y Peng, and
S Ma, and
S Zhang, and
Y Li, and
L Yang, and
S Bian
March 1990,
Deutsche medizinische Wochenschrift (1946),
Y Peng, and
S Ma, and
S Zhang, and
Y Li, and
L Yang, and
S Bian
February 1974,
Nihon Naibunpi Gakkai zasshi,
