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OBJECTIVE To explore the relationship between leptin's quantity in maternal blood, amniotic fluid, umbilical blood and maternal and newborn's weights. METHODS Levels of leptin in maternal blood, amniotic fluid, and umbilical blood of 34 pregnant women were detected by radioimmunoassay (RIA) method. Results were analyzed by the correlative analysis. RESULTS (1) Leptin can be detected either from maternal blood or amniotic fluid or umbilical blood. (2) There was an obvious correction between newborn's weight and leptin's quantity of maternal blood (relative coefficient r = 0.53, P < 0.01), amniotic fluid (r = 0.73, P < 0.01) and umbilical blood (r = 0.67, P < 0.01). (3) There was an obvious correction between maternal weight and leptin's quantity of maternal blood (r = 0.61, P < 0.01). (4) There was an obvious correction between leptin's quantity of amniotic fluid and umbilical blood (r = 0.72, P < 0.001). (5) There was not obvious correction between maternal weight and leptin's quantity of amniotic fluid and umbilical blood (r = 0.22, r = 0.18, respectively. P > 0.05). CONCLUSIONS It may be of important significance in detection of leptin's quantity in amniotic fluid and maternal blood in pregnant women for predicting the weight and growth of newborns.
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X Liu, and
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Neuropeptides,
