Biomaterial Database

[Clinical significance of sentinel lymph node biopsy in breast cancer]. 2000

B Zhang, and Y Bai, and G Chen

Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China.

OBJECTIVE To study the necessity, feasibility, accuracy and clinical value of sentinel lymph node(SLN) biopsy in the management of breast cancer. METHODS Technetium-99m labeled colloid particles were injected subcutaneously below the breast tumor before mastectomy. The sentinel lymph nodes identified by lymphoscintigraphy and gamma-counter were dissected out from the excised axillary tissue and separately examined manually for consistency and histologically. RESULTS In 30 cases studied, SLNs were identified in all but one, with a detection rate of 96.7%. Metastases were detected in SLNS in 8 cases. The other case showed positive axillary lymph nodes but SLN was negative. The sensitivity of SLN biopsy in this study was 88.9%, accuracy was 93.3%, false positive was 0, false negative was 11.1%. CONCLUSIONS SLN biopsy, though still under investigation, may in the future substitute routine axillary lymph node dissection in the management of breast cancer.

UI	MeSH Term	Description	Entries
D008207	Lymphatic Metastasis	Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.	Lymph Node Metastasis,Lymph Node Metastases,Lymphatic Metastases,Metastasis, Lymph Node
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011877	Radionuclide Imaging	The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.	Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D001943	Breast Neoplasms	Tumors or cancer of the human BREAST.	Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D005240	Feasibility Studies	Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.	Feasibility Study,Studies, Feasibility,Study, Feasibility
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D021701	Sentinel Lymph Node Biopsy	A diagnostic procedure used to determine whether LYMPHATIC METASTASIS has occurred. The SENTINEL LYMPH NODE is the first lymph node to receive drainage from a neoplasm.	Biopsy, Sentinel Lymph Node,Lymph Node Biopsy, Sentinel