-transparent.png){kind=logo}
OBJECTIVE To explore the mechanism of perinatal hypoxia-ischemia encephalopathy, we studied the expression of the c-fos gene and its relationship with delayed neuronal death in a rat model. METHODS Cerebral hypoxia-ischemia was produced in 7-day-old SD rats using the Rice model. Reverse transcription PCR (RT-PCR), immunohistochemistry and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) were used to detect the expression of c-fos gene and cell apoptosis in the hippocampus. RESULTS The selective expression of c-fos and delayed cell apoptosis were observed in the hypoxia-ischemia hippocampus. Expression of the c-fos gene was seen in the CA4 and cingulate sulcus neurons, and apoptosis was observed in the CA1 neurons. CONCLUSIONS Transient expression of the c-fos gene may induce cerebral cell apoptosis, and may have complex relations with delayed cell death.
L Jiang, and
Y Ding, and
Y Tang
March 2001,
The Journal of comparative neurology,
L Jiang, and
Y Ding, and
Y Tang
November 2014,
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
L Jiang, and
Y Ding, and
Y Tang
July 1993,
Toxicology and applied pharmacology,
L Jiang, and
Y Ding, and
Y Tang
June 1984,
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism,
L Jiang, and
Y Ding, and
Y Tang
January 1984,
Acta neuropathologica,
L Jiang, and
Y Ding, and
Y Tang
September 2019,
Behavioural brain research,
L Jiang, and
Y Ding, and
Y Tang
June 2004,
Zhonghua er ke za zhi = Chinese journal of pediatrics,
L Jiang, and
Y Ding, and
Y Tang
October 1994,
Neuroscience letters,
L Jiang, and
Y Ding, and
Y Tang
August 1994,
Anesthesiology,
L Jiang, and
Y Ding, and
Y Tang
May 1982,
Brain research,
