Effects of yohimbine and apomorphine on the male sexual behaviour pattern of the golden hamster (Mesocricetus auratus). 2002

M Arteaga, and J Motte-Lara, and J Velázquez-Moctezuma
Departamento de Biología de la Reproducción, Universidad Autónoma Metropolitana, Iztapalapa, Apartado Postal 55 535, 09340, Mexico City C.P., Mexico.

It has been reported that the copulatory pattern of male hamsters differs from that displayed by most rodents. Besides mount, intromission and ejaculatory patterns, male hamsters display a peculiar copulatory pattern known as long intromission (LI). This peculiar behavioural pattern emerges after the male has been allowed to ejaculate repeatedly. Although LIs have been linked to sexual exhaustion, their functional meaning and their pharmacological regulation have not yet been elucidated. In this study, the sexual behaviour pattern of male golden hamsters was analysed after the administration of yohimbine and apomorphine, drugs that selectively acts on the noradrenergic and dopaminergic system, respectively. Both drugs have proved effective in inducing facilitation of masculine sexual behaviour in several species, including rodents. Results showed that, as in rats, the administration of yohimbine and apomorphine in male hamsters seems to have a stimulatory effect on masculine sexual behaviour, although their effects differ in characteristics and in intensity. In particular, after yohimbine administration, the onset of LIs appears sooner than in control subjects and it seems that they are linked to the number of ejaculations. In addition, sexual activity seems increased after the onset of LIs, including an increase in ejaculations and in the number of LIs. On the other hand, apomorphine administration induced just a slight stimulatory effect limited to ejaculatory latency and postejaculatory interval. Concerning LIs, apomorphine induced a complete disappearance of LIs in 60% of the subjects. The full significance of these findings remains to be elucidated.

UI MeSH Term Description Entries
D008297 Male Males
D008647 Mesocricetus A genus in the order Rodentia and family Cricetidae. One species, Mesocricetus auratus or golden hamster is widely used in biomedical research. Hamsters, Golden,Hamsters, Golden Syrian,Hamsters, Syrian,Mesocricetus auratus,Syrian Golden Hamster,Syrian Hamster,Golden Hamster,Golden Hamster, Syrian,Golden Hamsters,Golden Syrian Hamsters,Hamster, Golden,Hamster, Syrian,Hamster, Syrian Golden,Syrian Hamsters
D005260 Female Females
D006224 Cricetinae A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS. Cricetus,Hamsters,Hamster
D000317 Adrenergic alpha-Antagonists Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. Adrenergic alpha-Receptor Blockaders,alpha-Adrenergic Blocking Agents,alpha-Adrenergic Receptor Blockaders,alpha-Blockers, Adrenergic,Adrenergic alpha-Blockers,alpha-Adrenergic Antagonists,alpha-Adrenergic Blockers,Adrenergic alpha Antagonists,Adrenergic alpha Blockers,Adrenergic alpha Receptor Blockaders,Agents, alpha-Adrenergic Blocking,Antagonists, alpha-Adrenergic,Blockaders, Adrenergic alpha-Receptor,Blockaders, alpha-Adrenergic Receptor,Blockers, alpha-Adrenergic,Blocking Agents, alpha-Adrenergic,Receptor Blockaders, alpha-Adrenergic,alpha Adrenergic Antagonists,alpha Adrenergic Blockers,alpha Adrenergic Blocking Agents,alpha Adrenergic Receptor Blockaders,alpha Blockers, Adrenergic,alpha-Antagonists, Adrenergic,alpha-Receptor Blockaders, Adrenergic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001058 Apomorphine A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use. Apokinon,Apomorphin-Teclapharm,Apomorphine Chloride,Apomorphine Hydrochloride,Apomorphine Hydrochloride Anhydrous,Apomorphine Hydrochloride, Anhydrous,Apomorphine Hydrochloride, Hemihydrate,Britaject,Apomorphin Teclapharm
D012726 Sexual Behavior, Animal Sexual activities of animals. Mating Behavior, Animal,Sex Behavior, Animal,Animal Mating Behavior,Animal Mating Behaviors,Animal Sex Behavior,Animal Sex Behaviors,Animal Sexual Behavior,Animal Sexual Behaviors,Mating Behaviors, Animal,Sex Behaviors, Animal,Sexual Behaviors, Animal
D015016 Yohimbine A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION. Rauwolscine,Aphrodine Hydrochloride,Aphrodyne,Corynanthine,Corynanthine Tartrate,Pluriviron,Rauhimbine,Yocon,Yohimbin Spiegel,Yohimbine Houdé,Yohimbine Hydrochloride,Yohimex,Hydrochloride, Aphrodine,Hydrochloride, Yohimbine,Tartrate, Corynanthine
D018491 Dopamine Agonists Drugs that bind to and activate dopamine receptors. Dopamine Receptor Agonists,Dopaminergic Agonists,Agonists, Dopamine Receptor,Agonists, Dopaminergic,Dopamine Agonist,Dopamine Receptor Agonist,Dopaminergic Agonist,Receptor Agonists, Dopamine,Agonist, Dopamine,Agonist, Dopamine Receptor,Agonist, Dopaminergic,Agonists, Dopamine,Receptor Agonist, Dopamine

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