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In order to determine the ability of single-breath nitrogen closing volume (CV) to detect early airway obstruction, the CV was measured in patients with either minimal obstruction of spirometry or with increased residual volume (RV). A total of 39 subjects was included in this study. The mean CV was largest in patients who had reduced maximum mid-expiratory flow rates (MMF). There was no difference in mean CV between smokers and the patients who had large RV but no airway obstruction, although both groups had higher mean CV than ex-smokers. Normal CV was seen in four of 11 patients who had reduced MMF and in four of seven who had large RV but no airway obstruction. All ex-smokers had normal CV while five of 12 smokers had adnormal CV. The results indicate that the closing volume should be used to complement spirometry, rather than to replace it, for screening of early airway obstruction.
A Funahashi, and
G N Melville, and
L H Hamilton
August 1989,
Clinical physiology (Oxford, England),
A Funahashi, and
G N Melville, and
L H Hamilton
January 1974,
Scandinavian journal of respiratory diseases,
A Funahashi, and
G N Melville, and
L H Hamilton
April 1977,
Scandinavian journal of respiratory diseases,
A Funahashi, and
G N Melville, and
L H Hamilton
January 1981,
Bulletin europeen de physiopathologie respiratoire,
A Funahashi, and
G N Melville, and
L H Hamilton
August 1976,
Journal of applied physiology,
A Funahashi, and
G N Melville, and
L H Hamilton
December 2007,
The journal of physiological sciences : JPS,
A Funahashi, and
G N Melville, and
L H Hamilton
November 1981,
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,
A Funahashi, and
G N Melville, and
L H Hamilton
February 1975,
Praxis der Pneumologie,
A Funahashi, and
G N Melville, and
L H Hamilton
May 1978,
The American review of respiratory disease,
A Funahashi, and
G N Melville, and
L H Hamilton
December 1977,
The American review of respiratory disease,
