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Hypothalamo-hypophysial-thyroid function has been studied in twenty-five patients with chronic renal failure. Eight were receiving conservative treatment, nine peritoneal dialysis and eight haemodialysis. All were clinically euthyroid. Total thyroxine (T4) and triiodothyronine (T3) levels were reduced but free T4 levels were normal, while free T3 was reduced in patients with the most severe renal failure. It is suggested that the binding of thyroid hormones by the transport proteins is reduced and that peripheral conversion of T4 to T3 is impaired in renal failure. The thyrotrophin response to thyrotrophin-releasing hormone (TRH) is reduced in renal failure but this reduction is probably independent of alterations in thyroid hormone metabolism. Growth hormone was released by TRH in seven of the patients studied, possibly as a result of protein malnutrition.
A Gomez-Pan, and
F Alvarez-Ude, and
P P Yeo, and
R Hall, and
D C Evered, and
D N Kerr
January 1992,
Endocrinology,
A Gomez-Pan, and
F Alvarez-Ude, and
P P Yeo, and
R Hall, and
D C Evered, and
D N Kerr
March 1993,
Endocrinology and metabolism clinics of North America,
A Gomez-Pan, and
F Alvarez-Ude, and
P P Yeo, and
R Hall, and
D C Evered, and
D N Kerr
January 1993,
Postepy higieny i medycyny doswiadczalnej,
A Gomez-Pan, and
F Alvarez-Ude, and
P P Yeo, and
R Hall, and
D C Evered, and
D N Kerr
September 1956,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
A Gomez-Pan, and
F Alvarez-Ude, and
P P Yeo, and
R Hall, and
D C Evered, and
D N Kerr
August 1975,
Archives internationales de physiologie et de biochimie,
A Gomez-Pan, and
F Alvarez-Ude, and
P P Yeo, and
R Hall, and
D C Evered, and
D N Kerr
November 1983,
Kidney international. Supplement,
A Gomez-Pan, and
F Alvarez-Ude, and
P P Yeo, and
R Hall, and
D C Evered, and
D N Kerr
January 1981,
Bollettino della Societa italiana di biologia sperimentale,
A Gomez-Pan, and
F Alvarez-Ude, and
P P Yeo, and
R Hall, and
D C Evered, and
D N Kerr
November 1996,
International journal of urology : official journal of the Japanese Urological Association,
A Gomez-Pan, and
F Alvarez-Ude, and
P P Yeo, and
R Hall, and
D C Evered, and
D N Kerr
January 1977,
Proceedings of the Clinical Dialysis and Transplant Forum,
A Gomez-Pan, and
F Alvarez-Ude, and
P P Yeo, and
R Hall, and
D C Evered, and
D N Kerr
January 1984,
Terapevticheskii arkhiv,
